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Am J Physiol Heart Circ Physiol (July 1, 2005). doi:10.1152/ajpheart.01270.2004
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Submitted on December 16, 2004
Accepted on June 29, 2005

Regulation of capillary hydraulic conductivity in response to an acute change in shear

Min-ho Kim1, Norman R Harris2*, and John M Tarbell3

1 Bioengineering, Pennsylvania State University, University Park, PA, USA; Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
2 Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
3 Biomedical Engineering, The City College of New York/CUNY, New York, NY, USA

* To whom correspondence should be addressed. E-mail: nharr6{at}lsuhsc.edu.

The effects of mechanical perturbations (shear stress, pressure) on microvascular permeability primarily have been examined in micropipette-cannulated vessels or in endothelial monolayers in vitro. The objective of this study is to determine whether acute changes in blood flow shear stress might influence measurements of hydraulic conductivity (Lp) in autoperfused microvessels in vivo. Rat mesenteric microvessels were observed via intravital microscopy. Occlusion of a third-order arteriole with a micropipette was used to divert and increase flow through a non-occluded capillary or fourth-order arteriolar branch. Transvascular fluid filtration rate in the branching vessel was measured with a Landis technique. Flow (shear)-induced increases in Lp disappeared within 20-30 s of the removal of the shear and could be eliminated with nitric oxide synthase inhibition. The shear-induced increase in Lp was greater in capillaries compared to terminal arterioles. An acute change in shear may regulate Lp by a nitric oxide-dependent mechanism that displays heterogeneity within a microvascular network.




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