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1 Heart Institute (InCor), University of Sao Paulo, Medical School, Sao Paulo, Brazil
2 School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil
3 Department of Cardiology, University of California, Los Angeles, Medical School, Los Angeles, California, United States
4 Heart Institute (InCor), University of Sao Paulo, Medical School, Sao Paulo, Brazil; School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil
* To whom correspondence should be addressed. E-mail: cndnegrao{at}incor.usp.br.
Exercise training improves arterial baroreflex control in heart failure (HF) rabbits. However, the mechanisms involved in the amelioration of baroreflex control are unknown. We tested the hypothesis that exercise training would increase the afferent aortic depressor nerve activity (AODN) sensitivity in ischemic-induced HF rats. Twenty ischemic-induced HF rats were divided in trained (n=11) and untrained (n=9) groups. Nine normal control rats were also studied. Power spectral analysis of pulse interval, systolic blood pressure, renal sympathetic nerve activity (RSNA), and AODN were analyzed by means of autoregressive parametric spectral and cross-spectral algorithms. Spontaneous baroreflex sensitivity of heart rate (HR) and RSNA were analyzed during spontaneous variation of systolic blood pressure. Left ventricular end-diastolic pressure was higher in HF rats compared to normal control group (P=0.0001). Trained HF rats had a VO2peak higher than untrained rats and similar to normal controls (P=0.01). Trained HF rats had lower low frequency (1.8±0.2 vs. 14.6±3NU, P=0.0003) and higher high frequency (97.9±0.2 vs. 85.0±3NU P=0.0005) components of pulse interval than untrained rats. Trained HF rats had higher spontaneous baroreceptor sensitivity of HR (1.19±0.2 vs. 0.51±0.1ms/mmHg, P=0.003) and RSNA (2.69±0.4 vs. 1.29±0.3au/mmHg P=0.04) than untrained rats. In HF rats, exercise training increased spontaneous AODN sensitivity towards normal levels (Trained HF=1791±215, Untrained HF=1150±158, and normal control =2064±327au/mmHg, P=0.05). In conclusion, exercise training improves AODN sensitivity in HF rats.
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