| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 236, Issue 6 818-H827, Copyright © 1979 by American Physiological Society
ARTICLES |
M. Rabinovitch, W. Gamble, A. S. Nadas, O. S. Miettinen and L. Reid
In 55 Sprague-Dawley rats (mean wt, 277 +/- 6.2 g) exposed to hypobaric hypoxia (air at 380 mmHg), and 23 weight-matched controls kept in room air, pulmonary and systemic artery pressures were measured daily for 2 wk via indwelling catheters. After each day of exposure, 1 or 2 hypoxic rats, to a total of 20, and 5 control rats were killed during the experiment. In these rats, the pulmonary arterial tree was injected post mortem with barium-gelatin and inflated with formaldehyde solution, and three structural features were quantified microscopically: 1) abnormal extension of muscle into peripheral arteries where it is not normally present (EMPA); 2) increased wall thickness of the normally muscular arteries, expressed as a percentage of external diameter (%WT); and 3) reduction in artery number expressed as an increase in the ratio of alveoli to arteries (A/a). Mean pulmonary artery pressure (Ppa) rose significantly after day 3 of hypoxic exposure (P less than 0.05) and had doubled by day 14; the mean systemic artery pressure (Psa) of hypoxic rats and Ppa and Psa of control rats were unchanged. The level of Ppa correlated with the degree of structural changes; for EMPA, r = 0.84; for %WT, r = 0.64; and for A/a, r = 0.73 (P less than 0.001 in all.
This article has been cited by other articles:
|
|
 |
|
  X. Sun and D. D. Ku Rosuvastatin provides pleiotropic protection against pulmonary hypertension, right ventricular hypertrophy, and coronary endothelial dysfunction in rats Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H801 - H809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Archer, M. Gomberg-Maitland, M. L. Maitland, S. Rich, J. G. N. Garcia, and E. K. Weir Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1{alpha}-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H570 - H578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. O. Schwenke, J. T. Pearson, K. Kangawa, K. Umetani, and M. Shirai Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: assessed using synchrotron radiation microangiography J Appl Physiol, January 1, 2008; 104(1): 88 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. McLoughlin and I. McMurtry Counterpoint: Chronic Hypoxia-induced Pulmonary Hypertension does not Lead to Loss of Pulmonary Vasculature J Appl Physiol, October 1, 2007; 103(4): 1451 - 1453. [Full Text] [PDF]
|
|
|
|
 |
|
 S. de Frutos, R. Spangler, D. Alo, and L. V. G. Bosc NFATc3 Mediates Chronic Hypoxia-induced Pulmonary Arterial Remodeling with {alpha}-Actin Up-regulation J. Biol. Chem., May 18, 2007; 282(20): 15081 - 15089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O. Schwenke, J. T. Pearson, K. Umetani, K. Kangawa, and M. Shirai Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography J Appl Physiol, February 1, 2007; 102(2): 787 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kantores, P. J. McNamara, L. Teixeira, D. Engelberts, P. Murthy, B. P. Kavanagh, and R. P. Jankov Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L912 - L922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Sun and D. D. Ku Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2431 - H2438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Faber, C. L. Szymeczek, S. S. Salvi, and H. Zhang Enhanced {alpha}1-adrenergic trophic activity in pulmonary artery of hypoxic pulmonary hypertensive rats Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2272 - H2281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-F. Chen, J.-A. Feng, P. Li, D. Xing, Y. Zhang, R. Serra, N. Ambalavanan, E. Majid-Hassan, and S. Oparil Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling J Appl Physiol, February 1, 2006; 100(2): 564 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Sun and D. D. Ku Selective right, but not left, coronary endothelial dysfunction precedes development of pulmonary hypertension and right heart hypertrophy in rats Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H758 - H764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Favret, K. K. Henderson, J. Allen, J.-P. Richalet, and N. C. Gonzalez Exercise training improves lung gas exchange and attenuates acute hypoxic pulmonary hypertension but does not prevent pulmonary hypertension of prolonged hypoxia J Appl Physiol, January 1, 2006; 100(1): 20 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Littler, C. A. Wehling, M. J. Wick, K. A. Fagan, C. D. Cool, R. O. Messing, and E. C. Dempsey Divergent contractile and structural responses of the murine PKC-{epsilon} null pulmonary circulation to chronic hypoxia Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1083 - L1093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Rios, M. Fallon, J. Wang, and L. A. Shimoda Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L867 - L874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Kobs, N. E. Muvarak, J. C. Eickhoff, and N. C. Chesler Linked mechanical and biological aspects of remodeling in mouse pulmonary arteries with hypoxia-induced hypertension Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1209 - H1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Imamura, B. Luo, J. Limbird, A. Vitello, M. Oka, D. D. Ivy, I. F. McMurtry, C. V. Garat, M. B. Fallon, and E. P. Carter Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation J Appl Physiol, February 1, 2005; 98(2): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Molthen, K. L. Karau, and C. A. Dawson Quantitative models of the rat pulmonary arterial tree morphometry applied to hypoxia-induced arterial remodeling J Appl Physiol, December 1, 2004; 97(6): 2372 - 2384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. K. Sheares, T. K. Jeffery, L. Long, X. Yang, and N. W. Morrell Differential effects of TGF-{beta}1 and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L919 - L927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nagaoka, Y. Morio, N. Casanova, N. Bauer, S. Gebb, I. McMurtry, and M. Oka Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L665 - L672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pauvert, S. Bonnet, E. Rousseau, R. Marthan, and J.-P. Savineau Sildenafil alters calcium signaling and vascular tone in pulmonary arteries from chronically hypoxic rats Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L577 - L583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Deten, H. Millar, and H.-G. Zimmer Catheterization of pulmonary artery in rats with an ultraminiature catheter pressure transducer Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2212 - H2217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Azoulay, S. Eddahibi, E. Marcos, M. Levame, A. Harf, B. Schlemmer, S. Adnot, and C. Delclaux Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension J Appl Physiol, May 1, 2003; 94(5): 2027 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hoshikawa, P. Nana-Sinkam, M. D. Moore, S. Sotto-Santiago, T. Phang, R. L. Keith, K. G. Morris, T. Kondo, R. M. Tuder, N. F. Voelkel, et al. Hypoxia induces different genes in the lungs of rats compared with mice Physiol Genomics, February 6, 2003; 12(3): 209 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yang, K. K. K. Sheares, N. Davie, P. D. Upton, G. W. Taylor, J. Horsley, J. Wharton, and N. W. Morrell Hypoxic Induction of Cox-2 Regulates Proliferation of Human Pulmonary Artery Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol., December 1, 2002; 27(6): 688 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Raj and L. Shimoda Oxygen-dependent signaling in pulmonary vascular smooth muscle Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L671 - L677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Le Cras, N. E. Markham, R. M. Tuder, N. F. Voelkel, and S. H. Abman Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L555 - L562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Chicoine, J. W. Avitia, C. Deen, L. D. Nelin, S. Earley, and B. R. Walker Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat J Appl Physiol, July 1, 2002; 93(1): 311 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-L. Lai, S.-J. Chu, M.-C. Ma, and C.-F. Chen Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R858 - R864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H.E. Zaidi, X.-M. You, S. Ciura, M. Husain, and M. Rabinovitch Overexpression of the Serine Elastase Inhibitor Elafin Protects Transgenic Mice From Hypoxic Pulmonary Hypertension Circulation, January 29, 2002; 105(4): 516 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Klinger, R. R. Warburton, L. Pietras, P. Oliver, J. Fox, O. Smithies, and N. S. Hill Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H58 - H65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Karau, R. C. Molthen, A. Dhyani, S. T. Haworth, C. C. Hanger, D. L. Roerig, R. H. Johnson, and C. A. Dawson Pulmonary arterial morphometry from microfocal X-ray computed tomography Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2747 - H2756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, O. Platoshyn, J. Zhang, S. Krick, Y. Zhao, L. J. Rubin, A. Rothman, and J. X.-J. Yuan c-Jun Decreases Voltage-Gated K+ Channel Activity in Pulmonary Artery Smooth Muscle Cells Circulation, September 25, 2001; 104(13): 1557 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhao, N. A. Mason, N. W. Morrell, B. Kojonazarov, A. Sadykov, A. Maripov, M. M. Mirrakhimov, A. Aldashev, and M. R. Wilkins Sildenafil Inhibits Hypoxia-Induced Pulmonary Hypertension Circulation, July 24, 2001; 104(4): 424 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. HOSHIKAWA, N. F. VOELKEL, T. L. GESELL, M. D. MOORE, K. G. MORRIS, L. A. ALGER, S. NARUMIYA, and M. W. GERACI Prostacyclin Receptor-dependent Modulation of Pulmonary Vascular Remodeling Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 314 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bonnet, J.-M. Hyvelin, P. Bonnet, R. Marthan, and J.-P. Savineau Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L183 - L192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bonnet, A. Belus, J.-M. Hyvelin, E. Roux, R. Marthan, and J.-P. Savineau Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L193 - L201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, D. J. Manalo, J. S. K. Sham, G. L. Semenza, and J. T. Sylvester Partial HIF-1{alpha} deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L202 - L208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Henderson, R. L. Clancy, and N. C. Gonzalez Living and training in moderate hypoxia does not improve {V}O2 max more than living and training in normoxia J Appl Physiol, June 1, 2001; 90(6): 2057 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hoshikawa, S. Ono, S. Suzuki, T. Tanita, M. Chida, C. Song, M. Noda, T. Tabata, N. F. Voelkel, and S. Fujimura Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia J Appl Physiol, April 1, 2001; 90(4): 1299 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. van SUYLEN, W. M. AARTSEN, J. F. M. SMITS, and M. J. A. P. DAEMEN Dissociation of Pulmonary Vascular Remodeling and Right Ventricular Pressure in Tissue Angiotensin-converting Enzyme-deficient Mice Under Conditions of Chronic Alveolar Hypoxia Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1241 - 1245. [Abstract] [Full Text]
|
|
|
|
|
|
O. Platoshyn, Y. Yu, V. A. Golovina, S. S. McDaniel, S. Krick, L. Li, J.-Y. Wang, Lewis. J. Rubin, and J. X.-J. Yuan Chronic hypoxia decreases KV channel expression and function in pulmonary artery myocytes Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L801 - L812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Favret, J.-P. Richalet, K. K. Henderson, R. Germack, and N. C. Gonzalez Myocardial adrenergic and cholinergic receptor function in hypoxia: correlation with O2 transport in exercise Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R730 - R738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. O'Blenes, S. Fischer, B. McIntyre, S. Keshavjee, and M. Rabinovitch Hemodynamic unloading leads to regression of pulmonary vascular disease in rats J. Thorac. Cardiovasc. Surg., February 1, 2001; 121(2): 0279 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhao, A. Sebkhi, D. J. R. Nunez, L. Long, C. S. Haley, J. Szpirer, C. Szpirer, A. J. Williams, and M. R. Wilkins Right Ventricular Hypertrophy Secondary to Pulmonary Hypertension Is Linked to Rat Chromosome 17 : Evaluation of Cardiac Ryanodine Ryr2 Receptor as a Candidate Circulation, January 23, 2001; 103(3): 442 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Leon-Velarde, M.-C. Bourin, R. Germack, K. Mohammadi, B. Crozatier, and J.-P. Richalet Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R274 - R281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Partovian, S. Adnot, B. Raffestin, V. Louzier, M. Levame, I. M. Mavier, P. Lemarchand, and S. Eddahibi Adenovirus-Mediated Lung Vascular Endothelial Growth Factor Overexpression Protects against Hypoxic Pulmonary Hypertension in Rats Am. J. Respir. Cell Mol. Biol., December 1, 2000; 23(6): 762 - 771. [Abstract] [Full Text]
|
|
|
|
|
|
N. Jin, N. Hatton, D. R. Swartz, X.-l. Xia, M. A. Harrington, S. H. Larsen, and R. A. Rhoades Hypoxia Activates Jun-N-Terminal Kinase, Extracellular Signal-Regulated Protein Kinase, and p38 Kinase in Pulmonary Arteries Am. J. Respir. Cell Mol. Biol., November 1, 2000; 23(5): 593 - 601. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Shimoda, J. S. K. Sham, T. H. Shimoda, and J. T. Sylvester L-type Ca2+ channels, resting [Ca2+]i, and ET-1-induced responses in chronically hypoxic pulmonary myocytes Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L884 - L894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Walker, T. C. Resta, and L. D. Nelin Nitric oxide-dependent pulmonary vasodilation in polycythemic rats Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2382 - H2389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vieillard-Baron, E. Frisdal, S. Eddahibi, I. Deprez, A. H. Baker, A. C. Newby, P. Berger, M. Levame, B. Raffestin, S. Adnot, et al. Inhibition of Matrix Metalloproteinases by Lung TIMP-1 Gene Transfer or Doxycycline Aggravates Pulmonary Hypertension in Rats Circ. Res., September 1, 2000; 87(5): 418 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Le Cras, D.-H. Kim, N. E. Markham, and A. S. H. Abman Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L283 - L291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. L. Hanson, D. F. Boggs, J. M. Kay, S. E. Hofmeister, O. Okada, and W. W. Wagner Jr. Pulmonary vascular response of the coati to chronic hypoxia J Appl Physiol, March 1, 2000; 88(3): 981 - 986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chassagne, S. Eddahibi, C. Adamy, D. Rideau, F. Marotte, J.-L. Dubois-Randé, S. Adnot, J.-L. Samuel, and E. Teiger Modulation of Angiotensin II Receptor Expression during Development and Regression of Hypoxic Pulmonary Hypertension Am. J. Respir. Cell Mol. Biol., March 1, 2000; 22(3): 323 - 332. [Abstract] [Full Text]
|
|
|
|
|
|
H. Ooi, E. Cadogan, M. Sweeney, K. Howell, R. G. O'Regan, and P. McLoughlin Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling Am J Physiol Heart Circ Physiol, February 1, 2000; 278(2): H331 - H338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, N. Zhou, and R. A. Johns Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L841 - L847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Horstman, D. A. McCall, D. U. Frank, and G. F. Rich Inhaled Nitric Oxide and Nifedipine Have Similar Effects on Lung cGMP Levels in Rats Anesth. Analg., October 1, 1999; 89(4): 932 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, J. T. Sylvester, and J. S. K. Sham Chronic hypoxia alters effects of endothelin and angiotensin on K+ currents in pulmonary arterial myocytes Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L431 - L439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Maruyama, A. Yokochi, K. Maruyama, and S. Nosaka Acetylcholine-induced endothelium-derived contracting factor in hypoxic pulmonary hypertensive rats J Appl Physiol, May 1, 1999; 86(5): 1687 - 1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-W. Chen, C.-F. Chen, and Y.-L. Lai Chronic activation of neurokinin-1 receptor induces pulmonary hypertension in rats Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1543 - H1551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
