AJP - Heart and Circulatory Physiology, Vol 250, Issue 5 822-H827, Copyright © 1986 by American Physiological Society

ARTICLES

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

G. M. Rubanyi and P. M. Vanhoutte

Experiments were designed to determine the effects of oxygen-derived free radicals on the production and biological activity of endothelium-derived relaxing factor or factors released by acetylcholine. Rings of canine coronary arteries without endothelium (bioassay rings) were superfused with solution passing through a canine femoral artery with endothelium. Superoxide dismutase caused maximal relaxation of the bioassay ring when infused upstream, but not downstream, of the femoral artery; this effect of superoxide dismutase was inhibited by catalase. Infusion of acetylcholine relaxed the bioassay rings because it released a labile relaxing factor (or factors) from the endothelium. When infused below the femoral artery, superoxide dismutase and, to a lesser extent, catalase augmented the relaxations to acetylcholine. Superoxide dismutase, but not catalase, doubled the half-life of the endothelium-derived relaxing factor(s). This protective effect of the enzyme was augmented fivefold by lowering the oxygen content of the perfusate from 95 to 10%. These data demonstrate that: superoxide anions inactivate the relaxing factor(s) released by acetylcholine from endothelial cells and hyperoxia favors the inactivation of endothelium-derived relaxing factor(s).

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				S. Taddei, A. Virdis, L. Ghiadoni, S. Uleri, A. Magagna, and A. Salvetti Lacidipine Restores Endothelium-Dependent Vasodilation in Essential Hypertensive Patients Hypertension, December 1, 1997; 30(6): 1606 - 1612. [Abstract] [Full Text]

				S. Hoshida, N. Yamashita, J. Igarashi, K. Aoki, T. Kuzuya, and M. Hori Long-term Probucol Treatment Reverses the Severity of Myocardial Injury in Watanabe Heritable Hyperlipidemic Rabbits Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2801 - 2807. [Abstract] [Full Text]

				S. M. Lynch, B. Frei, J. D. Morrow, L. J. Roberts II, A. Xu, T. Jackson, R. Reyna, L. M. Klevay, J. A. Vita, and J. F. Keaney Jr. Vascular Superoxide Dismutase Deficiency Impairs Endothelial Vasodilator Function Through Direct Inactivation of Nitric Oxide and Increased Lipid Peroxidation Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2975 - 2981. [Abstract] [Full Text]

				S. Zollner, R. F. Haseloff, I. A. Kirilyuk, I. E. Blasig, and G. M. Rubanyi Nitroxides Increase the Detectable Amount of Nitric Oxide Released from Endothelial Cells J. Biol. Chem., September 12, 1997; 272(37): 23076 - 23080. [Abstract] [Full Text] [PDF]

				U. Solzbach, B. Hornig, M. Jeserich, and H. Just Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients Circulation, September 2, 1997; 96(5): 1513 - 1519. [Abstract] [Full Text]

				N. Abi-Gerges, T. Eschenhagen, L. Hove-Madsen, R. Fischmeister, and P.-F. Mery Methylene Blue Is a Muscarinic Antagonist in Cardiac Myocytes Mol. Pharmacol., September 1, 1997; 52(3): 482 - 490. [Abstract] [Full Text]