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AJP - Heart and Circulatory Physiology, Vol 266, Issue 6 2568-H2572, Copyright © 1994 by American Physiological Society
ARTICLES |
K. M. Mohazzab, P. M. Kaminski and M. S. Wolin
Department of Physiology, New York Medical College, Valhalla 10595.
In this study we examined the intracellular sources of superoxide anion (O2-.) in cultured bovine coronary endothelium, employing lucigenin (250 microM)-elicited chemiluminescence (CL). In the homogenate from these cells, 100 microM NADPH increased O2-. by 81% from 8.9 +/- 1.5 to 16.0 +/- 1.5 x 10(5) cpm/mg protein (P < 0.01, n = 8). In the presence of 100 microM NADH, however, CL increased by 458% from 8.9 +/- 1.6 to 49.6 +/- 12.0 x 10(5) cpm/mg protein (P < 0.01, n = 8). Scavengers of O2-., superoxide dismutase (100 micrograms/ml), or 4,5-dihydroxy-1,3-benzenedisulfonic acid disodium salt (Tiron, 10 mM) inhibited NADH-mediated CL by 70 and 83%, respectively. Neither hypoxanthine (100 microM) nor antimycin (10 microM)+succinate (5 mM) had any significant effect on basal CL levels, thereby excluding xanthine oxidase and mitochondria, respectively, as a detectable sources of O2-. generation. The presence of NAD+ (100 microM) and lactate (1 mM) increased CL by 88% (n = 8, P < 0.01). In the intact cells, basal production of CL was increased by 205% (P < 0.01) by 5 mM lactate, but not by 5 mM pyruvate, and CL was inhibited by 10 mM Tiron, suggesting the reduction of cytosolic NAD by lactate dehydrogenase stimulates O2-. production. Diphenyliodonium at 1 and 10 microM inhibited both NADH-mediated CL in homogenate and lactate-mediated CL in intact endothelium by 50 and 33%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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S. A. Gupte, T. Rupawalla, K. M. Mohazzab-H., and M. S. Wolin Regulation of NO-elicited pulmonary artery relaxation and guanylate cyclase activation by NADH oxidase and SOD Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1535 - H1542. [Abstract] [Full Text] [PDF] |
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H. D. Wang, S. Hope, Y. Du, M. T. Quinn, A. Cayatte, P. J. Pagano, and R. A. Cohen Paracrine Role of Adventitial Superoxide Anion in Mediating Spontaneous Tone of the Isolated Rat Aorta in Angiotensin II-Induced Hypertension Hypertension, May 1, 1999; 33(5): 1225 - 1232. [Abstract] [Full Text] [PDF] |
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A. Warnholtz, G. Nickenig, E. Schulz, R. Macharzina, J. H. Brasen, M. Skatchkov, T. Heitzer, J. P. Stasch, K. K. Griendling, D. G. Harrison, et al. Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis : Evidence for Involvement of the Renin-Angiotensin System Circulation, April 20, 1999; 99(15): 2027 - 2033. [Abstract] [Full Text] [PDF] |
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R. A. Cohen The potential clinical impact of 20 years of nitric oxide research Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1404 - H1407. [Full Text] [PDF] |
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C. O. Wambi-Kiesse and Z. S. Katusic Inhibition of copper/zinc superoxide dismutase impairs NO ·-mediated endothelium-dependent relaxations Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1043 - H1048. [Abstract] [Full Text] [PDF] |
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S. Seki, N. A. Flavahan, N. G. Smedira, and P. A. Murray Superoxide anion scavengers restore NO-mediated pulmonary vasodilation after lung transplantation Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H42 - H46. [Abstract] [Full Text] [PDF] |
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C. Sultana, Y. Shen, V. Rattan, C. Johnson, and V. K. Kalra Interaction of Sickle Erythrocytes With Endothelial Cells in the Presence of Endothelial Cell Conditioned Medium Induces Oxidant Stress Leading to Transendothelial Migration of Monocytes Blood, November 15, 1998; 92(10): 3924 - 3935. [Abstract] [Full Text] [PDF] |
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P. J. Pagano, S. J. Chanock, D. A. Siwik, W. S. Colucci, and J. K. Clark Angiotensin II Induces p67phox mRNA Expression and NADPH Oxidase Superoxide Generation in Rabbit Aortic Adventitial Fibroblasts Hypertension, August 1, 1998; 32(2): 331 - 337. [Abstract] [Full Text] [PDF] |
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X. Fang, N. L. Weintraub, C. D. Rios, D. A. Chappell, R. M. Zwacka, J. F. Engelhardt, L. W. Oberley, T. Yan, D. D. Heistad, and A. A. Spector Overexpression of Human Superoxide Dismutase Inhibits Oxidation of Low-Density Lipoprotein by Endothelial Cells Circ. Res., June 29, 1998; 82(12): 1289 - 1297. [Abstract] [Full Text] [PDF] |
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H. Okada, J. Woodcock-Mitchell, J. Mitchell, T. Sakamoto, K. Marutsuka, B. E. Sobel, and S. Fujii Induction of Plasminogen Activator Inhibitor Type 1 and Type 1 Collagen Expression in Rat Cardiac Microvascular Endothelial Cells by Interleukin-1 and Its Dependence on Oxygen-Centered Free Radicals Circulation, June 2, 1998; 97(21): 2175 - 2182. [Abstract] [Full Text] [PDF] |
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N. Inoue, S. Kawashima, K.-I. Hirata, Y. Rikitake, S. Takeshita, W. Yamochi, H. Akita, and M. Yokoyama Stretch force on vascular smooth muscle cells enhances oxidation of LDL via superoxide production Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H1928 - H1932. [Abstract] [Full Text] [PDF] |
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G. W. De Keulenaer, D. C. Chappell, N. Ishizaka, R. M. Nerem, R. W. Alexander, and K. K. Griendling Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State : Role of a Superoxide-Producing NADH Oxidase Circ. Res., June 1, 1998; 82(10): 1094 - 1101. [Abstract] [Full Text] [PDF] |
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A. M. Sheehy, M. A. Burson, and S. M. Black Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L833 - L841. [Abstract] [Full Text] [PDF] |
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H. Di Wang, P. J. Pagano, Y. Du, A. J. Cayatte, M. T. Quinn, P. Brecher, and R. A. Cohen Superoxide Anion From the Adventitia of the Rat Thoracic Aorta Inactivates Nitric Oxide Circ. Res., April 20, 1998; 82(7): 810 - 818. [Abstract] [Full Text] [PDF] |
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Y. Li, H. Zhu, P. Kuppusamy, V. Roubaud, J. L. Zweier, and M. A. Trush Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems J. Biol. Chem., January 23, 1998; 273(4): 2015 - 2023. [Abstract] [Full Text] [PDF] |
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N. Inoue, S. Kawashima, K. Kanazawa, S. Yamada, H. Akita, and M. Yokoyama Polymorphism of the NADH/NADPH Oxidase p22 phox Gene in Patients With Coronary Artery Disease Circulation, January 20, 1998; 97(2): 135 - 137. [Abstract] [Full Text] [PDF] |
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P. J. Pagano, J. K. Clark, M. E. Cifuentes-Pagano, S. M. Clark, G. M. Callis, and M. T. Quinn Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II PNAS, December 23, 1997; 94(26): 14483 - 14488. [Abstract] [Full Text] [PDF] |
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K. Hishikawa and T. F. Luscher Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells Circulation, November 18, 1997; 96(10): 3610 - 3616. [Abstract] [Full Text] |
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K. M. Mohazzab-H., P. M. Kaminski, and M. S. Wolin Lactate and PO2 Modulate Superoxide Anion Production in Bovine Cardiac Myocytes : Potential Role of NADH Oxidase Circulation, July 15, 1997; 96(2): 614 - 620. [Abstract] [Full Text] |
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C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, A. A. Quyyumi, and J. A. Panza Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients Hypertension, July 1, 1997; 30(1): 57 - 63. [Abstract] [Full Text] |
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M. Ushio-Fukai, A. M. Zafari, T. Fukui, N. Ishizaka, and K. K. Griendling p22phox Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells J. Biol. Chem., September 20, 1996; 271(38): 23317 - 23321. [Abstract] [Full Text] [PDF] |
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S. Rajagopalan and D. G. Harrison Reversing Endothelial Dysfunction With ACE Inhibitors: A New TREND? Circulation, August 1, 1996; 94(3): 240 - 243. [Full Text] |
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Q. Hu, G. Zheng, J. L. Zweier, S. Deshpande, K. Irani, and R. C. Ziegelstein NADPH Oxidase Activation Increases the Sensitivity of Intracellular Ca2+ Stores to Inositol 1,4,5-Trisphosphate in Human Endothelial Cells J. Biol. Chem., May 19, 2000; 275(21): 15749 - 15757. [Abstract] [Full Text] [PDF] |
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M. P. Merker, R. D. Bongard, N. J. Kettenhofen, Y. Okamoto, and C. A. Dawson Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L36 - L43. [Abstract] [Full Text] [PDF] |
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N. Li, F.-X. Yi, J. L. Spurrier, C. A. Bobrowitz, and A.-P. Zou Production of superoxide through NADH oxidase in thick ascending limb of Henle's loop in rat kidney Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1111 - F1119. [Abstract] [Full Text] [PDF] |
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