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Am J Physiol Heart Circ Physiol 282: H896-H901, 2002. First published November 8, 2001; doi:10.1152/ajpheart.00591.2001
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Vol. 282, Issue 3, H896-H901, March 2002

Increased expression of cardiotrophin-1 during ventricular remodeling in hypertensive rats

Yoshihito Takimoto1, Takeshi Aoyama1, Yoshitaka Iwanaga1, Toshiaki Izumi1, Yasuki Kihara1, Diane Pennica2, and Shigetake Sasayama1

1 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; and 2 Department of Molecular Oncology, Genentech Incorporated, South San Francisco, California 94080

Cardiotrophin-1 (CT-1) stimulates longitudinal myocardial cell hypertrophy. We examined the expression of CT-1, leukemia inhibitory factor (LIF), and gp130 by competitive RT-PCR and Western blotting in Dahl salt-sensitive (DS) rats with a high-salt diet, which showed a distinct transition from left ventricular hypertrophy (LVH) to congestive heart failure (CHF). The expression levels of CT-1 mRNA and protein were significantly increased at the CHF stage compared with the LVH stage and age-matched Dahl salt-resistant (DR) rats (n = 6 for each group). mRNA expression of LIF was not changed in the left ventricle at any stage by RT-PCR. gp130 mRNA and protein levels of DS rats at 11 and 17 wk were significantly increased compared with age-matched DR rats. The isolated myocyte length of DS rats at 17 wk was the longest among the four groups of rats. The LV end-diastolic dimension (LVDd) of DS rats, determined by echocardiography, was significantly increased at the CHF stage. There was a significant correlation between the CT-1 protein level and LVDd. CT-1 may play a role in ventricular remodeling during transition from LVH to CHF in the rat hypertensive model.

gp130; hypertension; left ventricular remodeling; congestive heart failure


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