AJP - Heart AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H1437-H1451, 2002. First published November 29, 2001; doi:10.1152/ajpheart.00489.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/4/H1437    most recent
00489.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kneller, J.
Right arrow Articles by Nattel, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kneller, J.
Right arrow Articles by Nattel, S.
Vol. 282, Issue 4, H1437-H1451, April 2002

Time-dependent transients in an ionically based mathematical model of the canine atrial action potential

James Kneller, Rafael J. Ramirez, Denis Chartier, Marc Courtemanche, and Stanley Nattel

Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada

Ionically based cardiac action potential (AP) models are based on equations with singular Jacobians and display time-dependent AP and ionic changes (transients), which may be due to this mathematical limitation. The present study evaluated transients during long-term simulated activity in a mathematical model of the canine atrial AP. Stimulus current assignment to a specific ionic species contributed to stability. Ionic concentrations were least disturbed with the K+ stimulus current. All parameters stabilized within 6-7 h. Inward rectifier, Na+/Ca2+ exchanger, L-type Ca2+, and Na+-Cl- cotransporter currents made the greatest contributions to stabilization of intracellular [K+], [Na+], [Ca2+], and [Cl-], respectively. Time-dependent AP shortening was largely due to the outward shift of Na+/Ca2+ exchange related to intracellular Na+ (Na<UP><SUB>i</SUB><SUP>+</SUP></UP>) accumulation. AP duration (APD) reached a steady state after ~40 min. AP transients also occurred in canine atrial preparations, with the APD decreasing by ~10 ms over 35 min, compared with ~27 ms in the model. We conclude that model APD and ionic transients stabilize with the appropriate stimulus current assignment and that the mathematical limitation of equation singularity does not preclude meaningful long-term simulations. The model agrees qualitatively with experimental observations, but quantitative discrepancies highlight limitations of long-term model simulations.

ionic drift; action potential transients; atrial fibrillation; electrophysiology; ion channels and transporters


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. A. Maltsev and E. G. Lakatta
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model
Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H594 - H615.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Jacquemet and C. S. Henriquez
Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2040 - H2052.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Tsujimae, S. Suzuki, S. Murakami, and Y. Kurachi
Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H660 - H669.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. Otway, J. I. Vandenberg, G. Guo, A. Varghese, M. L. Castro, J. Liu, J. Zhao, J. A. Bursill, K. R. Wyse, H. Crotty, et al.
Stretch-Sensitive KCNQ1 Mutation: A Link Between Genetic and Environmental Factors in the Pathogenesis of Atrial Fibrillation?
J. Am. Coll. Cardiol., February 6, 2007; 49(5): 578 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Zou, J. Kneller, L. J. Leon, and S. Nattel
Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1002 - H1012.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Krogh-Madsen, P. Schaffer, A. D. Skriver, L. K. Taylor, B. Pelzmann, B. Koidl, and M. R. Guevara
An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H398 - H413.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. J. Hund and Y. Rudy
Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model
Circulation, November 16, 2004; 110(20): 3168 - 3174.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. R. Ehrlich, T.-J. Cha, L. Zhang, D. Chartier, L. Villeneuve, T. E. Hebert, and S. Nattel
Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium
J. Physiol., June 1, 2004; 557(2): 583 - 597.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. R Ehrlich, T.-J. Cha, L. Zhang, D. Chartier, P. Melnyk, S. H Hohnloser, and S. Nattel
Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties
J. Physiol., September 15, 2003; 551(3): 801 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Cabo and P. A. Boyden
Electrical remodeling of the epicardial border zone in the canine infarcted heart: a computational analysis
Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H372 - H384.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Kneller, R. Zou, E. J. Vigmond, Z. Wang, L. J. Leon, and S. Nattel
Cholinergic Atrial Fibrillation in a Computer Model of a Two-Dimensional Sheet of Canine Atrial Cells With Realistic Ionic Properties
Circ. Res., May 17, 2002; 90 (9): e73 - e87.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online