AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H2198-H2209, 2002. First published February 21, 2002; doi:10.1152/ajpheart.00834.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/H2198    most recent
00834.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haitsma, D. B.
Right arrow Articles by Duncker, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haitsma, D. B.
Right arrow Articles by Duncker, D. J.
Vol. 282, Issue 6, H2198-H2209, June 2002

Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction

David B. Haitsma, Daphne Merkus, Jefrey Vermeulen, Pieter D. Verdouw, and Dirk J. Duncker

1 Experimental Cardiology, Thoraxcenter, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands

Left ventricular (LV) dysfunction caused by myocardial infarction (MI) is accompanied by endothelial dysfunction, most notably a loss of nitric oxide (NO) availability. We tested the hypothesis that endothelial dysfunction contributes to impaired tissue perfusion during increased metabolic demands as produced by exercise, and we determined the contribution of NO to regulation of regional systemic, pulmonary, and coronary vasomotor tone in exercising swine with LV dysfunction produced by a 2- to 3-wk-old MI. LV dysfunction resulted in blunted systemic and coronary vasodilator responses to ATP, whereas the responses to nitroprusside were maintained. Exercise resulted in blunted systemic and pulmonary vasodilator responses in MI that resembled the vasodilator responses in normal (N) swine following blockade of NO synthase with Nomega -nitro-L-arginine (L-NNA, 20 mg/kg iv). However, L-NNA resulted in similar decreases in systemic (43 ± 3% in N swine and 49 ± 4% in MI swine), pulmonary (45 ± 5% in N swine and 49 ± 4% in MI swine), and coronary (28 ± 4% in N and 35 ± 3% in MI) vascular conductances in N and MI swine under resting conditions; similar effects were observed during treadmill exercise. Selective inhibition of inducible NO synthase with aminoguanidine (20 mg/kg iv) had no effect on vascular tone in MI. These findings indicate that while agonist-induced vasodilation is already blunted early after myocardial infarction, the contribution of endothelial NO synthase-derived NO to regulation of vascular tone under basal conditions and during exercise is maintained.

coronary circulation; myocardial infarction; pulmonary circulation; regional blood flows; systemic circulation


This article has been cited by other articles:


Home page
 J. Physiol.Home page
D. Merkus, B. Houweling, V. J. de Beer, Z. Everon, and D. J. Duncker
Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarction
J. Physiol., May 1, 2007; 580(3): 907 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Merkus, D. B. Haitsma, O. Sorop, F. Boomsma, V. J. de Beer, J. M. J. Lamers, P. D. Verdouw, and D. J. Duncker
Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarction
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2082 - H2089.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Houweling, D. Merkus, O. Sorop, F. Boomsma, and D. J. Duncker
Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction
J. Physiol., July 15, 2006; 574(2): 615 - 626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Merkus, B. Houweling, M. van Vliet, and D. J. Duncker
Contribution of KATP+ channels to coronary vasomotor tone regulation is enhanced in exercising swine with a recent myocardial infarction
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1306 - H1313.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Merkus, B. Houweling, A. H. van den Meiracker, F. Boomsma, and D. J. Duncker
Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H871 - H880.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online