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Am J Physiol Heart Circ Physiol 283: H346-H352, 2002. First published March 28, 2002; doi:10.1152/ajpheart.01050.2001
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Vol. 283, Issue 1, H346-H352, July 2002

Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats

Fabrice Prunier1, Roger Gaertner1, Liliane Louedec1, Jean-Baptiste Michel1, Jean-Jacques Mercadier1,2, and Brigitte Escoubet2,3

1 Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 460, Faculté de Médecine Xavier Bichat; 2 AP-HP, Department of Physiology, Hôpital Bichat; and 3 INSERM Unité 426, Institut Fédératif de Recherche 02, Faculté de Médecine Xavier Bichat, 75018 Paris, France

The spectral Doppler mitral flow pattern, alone or combined with tissue Doppler mitral annulus velocity, can be used to predict left ventricular (LV) filling pressure in humans, whereas invasive hemodynamic measurements are still required in the rat. This study was undertaken to assess whether LV end-diastolic pressure (LVEDP) can be estimated using Doppler echocardiography in the rat after myocardial infarction (MI). Thirty-seven rats (23 rats with MI after left coronary artery ligation and 14 sham-operated rats) were evaluated 3 mo after surgery with echo-Doppler and invasive hemodynamic measurements. Pulse wave spectral Doppler at the mitral valve tip was used to measure the E wave, the E wave deceleration time (DT), and the A wave; spectral Doppler tissue imaging was used to measure the early diastolic lateral mitral annulus velocity (Ea). We found weak correlations between LVEDP and the peak velocity of the early mitral inflow (E), E/peak velocity of the late mitral inflow, and DT, and strong correlations with Ea and especially with E/Ea [R2 = 0.89, LVEDP (in mmHg) = 0.987E/Ea - 4.229]. Longitudinal followup of a subgroup of rats with MI revealed a marked rise of E/Ea between days 7 and 21 in rats with heart failure only. We conclude that Doppler echocardiography can be used for serial assessment of LV diastolic function in rats with MI.

myocardial infarction; echocardiography; heart failure; tissue Doppler imaging


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