AJP - Heart pressure measurements
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H69-H76, 2002. First published February 28, 2002; doi:10.1152/ajpheart.00817.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/1/H69    most recent
00817.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Csont, T.
Right arrow Articles by Ferdinandy, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Csont, T.
Right arrow Articles by Ferdinandy, P.
Vol. 283, Issue 1, H69-H76, July 2002

Nitrate tolerance does not increase production of peroxynitrite in the heart

Tamás Csont1, Csaba Csonka1, Annamária Ónody1, Anikó Görbe1, László Dux1, Richard Schulz2, Gary F. Baxter3, and Péter Ferdinandy1

1 Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, H-6720, Hungary; 2 Cardiovascular Research Group, Departments of Pharmacology and Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2R7; and 3 The Royal Veterinary College, University of London, London NW1 0TU, United Kingdom

Clinical studies have suggested that long-term nitrate treatment does not improve and may even worsen cardiovascular mortality, and the possible role of nitrate tolerance has been suspected. Nitrate tolerance has been recently shown to increase vascular superoxide and peroxynitrite production leading to vascular dysfunction. Nevertheless, nitrates exert direct cardiac effects independent from their vascular actions. Therefore, we investigated whether in vivo nitroglycerin treatment leading to vascular nitrate tolerance increases cardiac formation of nitric oxide (NO), reactive oxygen species, and peroxynitrite, thereby leading to cardiac dysfunction. Nitrate tolerance increased bioavailability of NO in the heart without increasing formation of reactive oxygen species. Despite elevated myocardial NO, neither cardiac markers of peroxynitrite formation nor cardiac mechanical function were affected by nitroglycerin treatment. However, serum free nitrotyrosine, a marker for systemic peroxynitrite formation, was significantly elevated in nitroglycerin-treated animals. This is the first demonstration that, although the systemic effects of nitroglycerin may be deleterious due to enhancement of extracardiac peroxynitrite formation, nitroglycerin does not result in oxidative damage in the heart.

nitroglycerin; nitric oxide; reactive oxygen species; myocardium


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
T. Csont, E. Bereczki, P. Bencsik, G. Fodor, A. Gorbe, A. Zvara, C. Csonka, L. G. Puskas, M. Santha, and P. Ferdinandy
Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice
Cardiovasc Res, October 1, 2007; 76(1): 100 - 109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Parent, N. Leblanc, and M. Lavallee
Nitroglycerin reduces myocardial oxygen consumption during exercise despite vascular tolerance
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1226 - H1234.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online