AJP - Heart pressure measurements
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H1681-H1687, 2002. First published June 13, 2002; doi:10.1152/ajpheart.00340.2002
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/H1681    most recent
00340.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Segers, P.
Right arrow Articles by Wouters, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Segers, P.
Right arrow Articles by Wouters, P. F.
Vol. 283, Issue 4, H1681-H1687, October 2002

Preload-adjusted maximal power of right ventricle: contribution of end-systolic P-V relation intercept

Patrick Segers1, H. Alex Leather2, Pascal Verdonck1, Yuan-Yuan Sun2, and Patrick F. Wouters2

1 Hydraulics Laboratory, Institute of Biomedical Technology, Ghent University, 9000 Ghent; and 2 Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium

To assess whether preload-adjusted maximal power (PAMP), which is calculated as Wmax/V<UP><SUB>ed</SUB><SUP>&bgr;</SUP></UP> (where Wmax is maximal power and Ved is end-diastolic volume with beta  = 2) is an index of right ventricular (RV) contractility, we measured RV pressure (P) and volume (V) and pulmonary artery pressure and flow in 10 dogs at baseline and after inotropic stimulation. PAMP was derived from steady-state data, whereas the slope (Ees) and intercept (Vd) of the end-systolic P-V relationship were derived from data obtained during vena caval occlusion. Inotropic stimulation increased Ees (from 0.96 ± 0.25 to 1.62 ± 0.28 mmHg/ml; P < 0.001) and Vd (from -3.0 ± 17.2 to 12.4 ± 10.8 ml; P < 0.05) but not PAMP (from 0.24 ± 0.10 to 0.36 ± 0.22 mW/ml2; P = 0.09). We found a strong relationship between the optimal beta -factor for preload adjustment and Vd. A corrected PAMP, PAMPc = Wmax/(Ved - Vd)2, which incorporated the Vd dependency, was sensitive to the inotropic changes (from 0.23 ± 0.12 to 0.54 ± 0.17 mW/ml2; P < 0.001) with a good correlation with Ees (r = 0.88; P < 0.001).

contractility; hydraulic; pressure-volume


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Schenk, Z. B. Popovic, Y. Ochiai, F. Casas, P. M. McCarthy, R. C. Starling, M. W. Kopcak Jr., R. Dessoffy, J. L. Navia, N. L. Greenberg, et al.
Preload-adjusted right ventricular maximal power: concept and validation
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1632 - H1640.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Segers, V. Tchana-Sato, H. A. Leather, B. Lambermont, A. Ghuysen, J.-M. Dogne, P. Benoit, P. Morimont, P. F. Wouters, P. Verdonck, et al.
Determinants of left ventricular preload-adjusted maximal power
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2295 - H2301.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online