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Am J Physiol Heart Circ Physiol 283: H1802-H1810, 2002. First published June 27, 2002; doi:10.1152/ajpheart.01096.2001
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Vol. 283, Issue 5, H1802-H1810, November 2002

Aldosterone induces a vascular inflammatory phenotype in the rat heart

Ricardo Rocha1, Amy E. Rudolph1, Gregory E. Frierdich1, Denise A. Nachowiak1, Beverly K. Kekec1, Eric A. G. Blomme2, Ellen G. McMahon1, and John A. Delyani1

1 Division of Cardiovascular and Metabolic Diseases and 2 Division of Global Toxicology, Pharmacia Corporation, Skokie, Illinois 60077 and St. Louis, Missouri 63141

Vascular inflammation was examined as a potential mechanism of aldosterone-mediated myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to drink for 1, 2, or 4 wk and 1) vehicle, 2) aldosterone infusion (0.75 µg/h), or 3) aldosterone infusion (0.75 µg/h) plus the selective aldosterone blocker eplerenone (100 mg · kg-1 · day-1). Aldosterone induced severe hypertension at 4 wk [systolic blood pressure (SBP), 210 ± 3 mmHg vs. vehicle, 131 ± 2 mmHg, P < 0.001], which was partially attenuated by eplerenone (SBP, 180 ± 7 mmHg; P < 0.001 vs. aldosterone alone and vehicle). No significant increases in myocardial interstitial collagen fraction or hydroxyproline concentration were detected throughout the study. However, histopathological analysis of the heart revealed severe coronary inflammatory lesions, which were characterized by monocyte/macrophage infiltration and resulted in focal ischemic and necrotic changes. The histological evidence of coronary lesions was preceded by and associated with the elevation of cyclooxygenase-2 (up to ~4-fold), macrophage chemoattractant protein-1 (up to ~4-fold), and osteopontin (up to ~13-fold) mRNA expression. Eplerenone attenuated proinflammatory molecule expression in the rat heart and subsequent vascular and myocardial damage. Thus aldosterone and salt treatment in uninephrectomized rats led to severe hypertension and the development of a vascular inflammatory phenotype in the heart, which may represent one mechanism by which aldosterone contributes to myocardial disease.

cyclooxygenase-2; osteopontin; macrophage chemoattractant protein-1; eplerenone


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[Full Text] [PDF]

Home page
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Home page
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