| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272-0095; and 2 Michael E. DeBakey Institute for Comparative Cardiovascular Science and Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4466
The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile response of control (Cont) aortas to VP was markedly higher in females (3,885 ± 332 mg/mg ring wt) than in males (810 ± 148 mg). Indomethacin (Indo; 10 µM) attenuated maximal response to VP in females (3,043 ± 277 mg) but not in males. SQ-29,548 (SQ; 1 µM) attenuated maximal response to VP in females (3,042 ± 290 mg) to a similar extent as Indo. Dazoxiben (Daz; 10 µM) alone had no effect, but Daz + SQ attenuated maximal contractile response to VP to a similar extent as SQ alone. Removal of the endothelium in female aortas attenuated contractile responses to VP in Cont aortas. OVX attenuated maximal contractile response to VP in Cont aortas (2,093 ± 329 mg) and abolished the attenuating effects of Indo. Indo, SQ, and Daz exerted identical effects on contractile responses of male, female, and OVX female aortas to PE. These findings establish the following in the rat aorta: 1) CP, probably thromboxane and/or endoperoxide, is responsible for ~25-30% of contractile responses of females, but not males, to VP and PE; 2) CP production by the female aorta is primarily endothelial in origin; and 3) ovarian steroids modulate production and/or actions of CP in female aortas.
constrictor prostanoids; thromboxane; vasoconstriction; vascular reactivity; aortic rings; vasopressin; endoperoxide
This article has been cited by other articles:
|
|
 |
|
  M. Li, L. Kuo, and J. N. Stallone Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2444 - H2455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Sellers and J. N. Stallone Sympathy for the devil: the role of thromboxane in the regulation of vascular tone and blood pressure Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H1978 - H1986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P Cooke and J. M Marshall Mechanisms of Raynaud's disease Vascular Medicine, November 1, 2005; 10(4): 293 - 307. [Abstract] [PDF]
|
|
|
|
|
|
M. Li and J. N. Stallone Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1542 - H1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. H. Huxley, J. Wang, and S. P. Whitt Sexual dimorphism in the permeability response of coronary microvessels to adenosine Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H2006 - H2013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Voss, J. N. Stallone, M. Li, R. N. M. Cornelussen, P. Knuefermann, and A. A. Knowlton Gender differences in the expression of heat shock proteins: the effect of estrogen Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H687 - H692. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
