AJP - Heart AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H542-H548, 2003. First published October 10, 2002; doi:10.1152/ajpheart.00608.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/H542    most recent
00608.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ten Tusscher, K. H. W. J.
Right arrow Articles by Panfilov, A. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ten Tusscher, K. H. W. J.
Right arrow Articles by Panfilov, A. V.
Vol. 284, Issue 2, H542-H548, February 2003

Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model

K. H. W. J. Ten Tusscher and A. V. Panfilov

Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands

Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper, we studied the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of K+ current or inward rectifying K+ current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed toward regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications.

ionic model; spiral wave; reentrant arrhythmias; tissue heterogeneity


This article has been cited by other articles:


Home page
 Circ. Res.Home page
K. H.W.J. Ten Tusscher, R. Hren, and A. V. Panfilov
Organization of Ventricular Fibrillation in the Human Heart
Circ. Res., June 22, 2007; 100(12): e87 - e101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Baher, Z. Qu, A. Hayatdavoudi, S. T. Lamp, M.-J. Yang, F. Xie, S. Turner, A. Garfinkel, and J. N. Weiss
Short-term cardiac memory and mother rotor fibrillation
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H180 - H189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Cabo and P. A. Boyden
Heterogeneous gap junction remodeling stabilizes reentrant circuits in the epicardial border zone of the healing canine infarct: a computational study
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2606 - H2616.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Qu
Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillation
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H255 - H263.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online