| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Hypertension and Vascular Research Division, and 2 Biostatistics Department, Henry Ford Health System, Detroit, Michigan 48202
Premenopausal women are much less prone
to develop cardiovascular disease than men of similar age, but this
advantage no longer applies after menopause. We previously found that
male mice have a significantly higher rate of cardiac rupture than
females during the acute phase of myocardial infarction (MI); however,
the effects of sexual hormones on chronic remodeling are unknown. We
hypothesized that estrogen (E) may protect the heart from chronic
remodeling and deterioration of function post-MI, whereas testosterone
(T) may have adverse effects. Mice (4 wk old) of both genders were divided into four groups: female groups consisted of 1) sham
ovariectomy (S-Ovx) + placebo (P) (S-Ovx + P), 2)
S-Ovx + T, 3) Ovx + P, and 4) Ovx + T; and male groups consisted of 1) sham castration
(S-Cas)+ P (S-Cas + P), 2) S-Cas + 17
-estradiol
(E), 3) Cas + P, and 4) Cas + E. MI was
induced 6 wk later. Echocardiography was performed to assess cardiac
function and left ventricular dimensions (LVD). Myocyte cross-sectional
area (MCSA) was measured at the end of the study. In females, both
testosterone and ovariectomy decreased ejection fraction (EF) and
increased LVD, and when combined they aggravated cardiac function and
remodeling further. Testosterone significantly increased MCSA. In
males, castration or estrogen increased EF and reduced LVD, whereas
castration significantly reduced MCSA. Our data suggest that estrogen
prevents deterioration of cardiac function and remodeling after MI, but
testosterone worsens cardiac dysfunction and remodeling and has a
pronounced effect when estrogen levels are reduced.
sexual hormones; cardiac dysfunction
This article has been cited by other articles:
|
|
 |
|
  E. A. Jankowska, P. Rozentryt, B. Ponikowska, O. Hartmann, D. Kustrzycka-Kratochwil, K. Reczuch, J. Nowak, L. Borodulin-Nadzieja, L. Polonski, W. Banasiak, et al. Circulating Estradiol and Mortality in Men With Systolic Chronic Heart Failure JAMA, May 13, 2009; 301(18): 1892 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W.M. Schellings, D. Vanhoutte, M. Swinnen, J. P. Cleutjens, J. Debets, R. E.W. van Leeuwen, J. d'Hooge, F. Van de Werf, P. Carmeliet, Y. M. Pinto, et al. Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction J. Exp. Med., January 16, 2009; 206(1): 113 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zhan, T. Keimig, J. Xu, E. Peterson, J. Ding, F. Wang, and X.-P. Yang Dose-dependent cardiac effect of oestrogen replacement in mice post-myocardial infarction Exp Physiol, August 1, 2008; 93(8): 982 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ray, C. M. Herring, T. A. Markel, P. R. Crisostomo, M. Wang, B. Weil, T. Lahm, and D. R. Meldrum Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1498 - R1503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Konhilas and L. A. Leinwand The Effects of Biological Sex and Diet on the Development of Heart Failure Circulation, December 4, 2007; 116(23): 2747 - 2759. [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Hydock, C.-Y. Lien, C. M. Schneider, and R. Hayward Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3254 - H3264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mukherjee, J. T. Mingoia, J. A. Bruce, J. S. Austin, R. E. Stroud, G. P. Escobar, D. M. McClister Jr, C. M. Allen, M. A. Alfonso-Jaume, M. E. Fini, et al. Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2216 - H2228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Dean, J. Tan, R. White, E. R. O'Brien, and F. H. H. Leenen Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R155 - R162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Cavasin, Z.-Y. Tao, A.-L. Yu, and X.-P. Yang Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H2043 - H2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Milne, D. B. Thorp, C. W. J. Melling, and E. G. Noble Castration inhibits exercise-induced accumulation of Hsp70 in male rodent hearts Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1610 - H1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Pitcher, M. Wang, B. M. Tsai, A. Kher, N. T. Nelson, and D. R. Meldrum Endogenous estrogen mediates a higher threshold for endotoxin-induced myocardial protection in females Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R27 - R33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Mendelsohn and R. H. Karas Molecular and Cellular Basis of Cardiovascular Gender Differences Science, June 10, 2005; 308(5728): 1583 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, O. A. Carretero, Y. Sun, E. G. Shesely, N.-E. Rhaleb, Y.-H. Liu, T.-D. Liao, J. J. Yang, M. Bader, and X.-P. Yang Role of the B1 Kinin Receptor in the Regulation of Cardiac Function and Remodeling After Myocardial Infarction Hypertension, April 1, 2005; 45(4): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pelzer, P.-A. A. Loza, K. Hu, B. Bayer, C. Dienesch, L. Calvillo, J. F. Couse, K. S. Korach, L. Neyses, and G. Ertl Increased Mortality and Aggravation of Heart Failure in Estrogen Receptor-{beta} Knockout Mice After Myocardial Infarction Circulation, March 29, 2005; 111(12): 1492 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-M. Gao, Q. Xu, H. Kiriazis, A. M. Dart, and X.-J. Du Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology Cardiovasc Res, February 1, 2005; 65(2): 469 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wang, B. M. Tsai, A. Kher, L. B. Baker, G. M. Wairiuko, and D. R. Meldrum Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H221 - H226. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
