AJP - Heart AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H1631-H1637, 2003. First published January 23, 2003; doi:10.1152/ajpheart.00909.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/5/H1631    most recent
00909.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iliff, J. J.
Right arrow Articles by Winn, H. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iliff, J. J.
Right arrow Articles by Winn, H. R.
Vol. 284, Issue 5, H1631-H1637, May 2003

Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex

Jeffrey J. Iliff1, Raimondo D'Ambrosio1, Al C. Ngai1, and H. Richard Winn2

Departments of 1 Neurological Surgery and 2 Biophysics and Physiology, University of Washington School of Medicine, Seattle, Washington 98104

We tested the hypothesis that adenosine (Ado) mediates glutamate-induced vasodilation in the cerebral cortex by monitoring pial arteriole diameter in chloralose-anesthetized rats equipped with closed cranial windows. Topical application of 100 µM glutamate and 100 µM N-methyl-D-aspartate (NMDA) dilated pial arterioles (baseline diameter 25 ± 2 µm) by 17 ± 1% and 18 ± 4%, respectively. Coapplication of the nonselective Ado receptor antagonist theophylline (Theo; 10 µM) significantly reduced glutamate- and NMDA-induced vasodilation to 4 ± 2% (P < 0.01) and 6 ± 2% (P < 0.05), whereas the Ado A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (0.1 µM) had no effect. Moreover, application of the Ado A2A receptor-selective antagonist 4-{2-[7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5)triazin-5-ylamino]ethyl}phenol (ZM-241385), either by superfusion (0.1 µM, 1 µM) or intravenously (1 mg/kg), significantly inhibited the pial arteriole dilation response to glutamate. Neither Theo nor ZM-241385 affected vascular reactivity to mild hypercapnia induced by 5% CO2 inhalation. These results suggest that Ado contributes to the dilation of rat cerebral arterioles induced by exogenous glutamate, and that the Ado A2A receptor subtype may be involved in this dilation response.

theophylline; 4-{2-[7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5)triazin-5-ylamino]ethyl}phenol; cerebral blood flow


This article has been cited by other articles:


Home page
 IOVSHome page
K. Holmgaard, C. Aalkjaer, J. D. C. Lambert, and T. Bek
N-Methyl-D-Aspartic Acid Causes Relaxation of Porcine Retinal Arterioles through an Adenosine Receptor-Dependent Mechanism
Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4590 - 4594.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ohata, S. Cao, and R. C. Koehler
Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R728 - R735.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Ayata and M. A. Moskowitz
Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1837 - H1841.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Koehler, D. Gebremedhin, and D. R. Harder
Role of astrocytes in cerebrovascular regulation
J Appl Physiol, January 1, 2006; 100(1): 307 - 317.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online