HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 285/3/H1286    most recent 00276.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Mazzadi, A. N. Articles by Janier, M. Search for Related Content PubMed PubMed Citation Articles by Mazzadi, A. N. Articles by Janier, M.

Cardiac retention of [¹¹C]HED in genotyped long QT patients: a potential amplifier role for severity of the disease

¹Centre d'Exploration et de Recherche Médicales par Émission de Positons, 69003 Lyon; ²Centre de Recherche et d'Applications en Traitement de l'Image et du Signal, Unité Mixed de Recherche-Centre National de Recherche Scientifique 5515, 69394 Lyon; ³Hôpital Cardiovasculaire et Pneumologique et Université Claude Bernard, 6934 Cedex 03 Lyon; ⁴Unité 533, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Formation et Recherche de Medecine, Hôpital Laënnec, Nantes 44035; and ⁵Unité 523, INSERM, Institut de Myologie, Groupe Hospitalier Pitié-Salpétrière, Paris 75013, France

Submitted 27 March 2003 ; accepted in final form 22 May 2003

Although mutations in cardiac sodium and potassium channel genes are associated with congenital long QT syndrome (LQTS), a "modifier" role of the sympathetic nervous system was proposed to explain the distinct severity of the disease. We evaluated cardiac sympathetic innervation using [¹¹C]hydroxyephedrine ([¹¹C]HED) and positron emission tomography (PET) in genotyped LQTS patients. H₂¹⁵O and [¹¹C]HED PET studies were performed in 11 patients (5 symptomatic) and 8 controls. Perfusion and [¹¹C]HED images were depicted as 36-sector polar maps. Sectorial values of perfusion (H₂O_%), absolute (HED_Ret) and relative retention (HED_%Ret) of [¹¹C]HED, and the ratio of HED_%Ret to H₂O_% (HED_%Ret/H₂O_%) were calculated. Normal databases were obtained from controls. Sectorial values below 2SD database values were defined as "outside sectors." Controls and patients showed similar sectorial perfusion. Sectorial HED_Ret did not differ between groups, but means of HED_%Ret were lower in three sectors for patients (P < 0.05). Three sectors from 3 controls had HED_%Ret below 2SD, whereas 36 sectors in 9 patients were outside sectors (P < 0.01). In patients, average HED_%Ret/H₂O_% was lower in 9 sectors (P < 0.05 vs. controls); 2 outside sectors were found in controls, but 43 outside sectors were found in patients (P < 0.01), 77% of them in the 5 symptomatic patients. Heterogeneous [¹¹C]HED retention was localized in the septal, anterior, and lateral walls. Most LQTS patients showed a localized and decreased pattern of [¹¹C]HED retention. The larger number of heterogeneous sectors in symptomatic patients suggests that sympathetic function could play an amplifier role for severity of the disease.

long QT syndrome; genetics; positron emission tomography; sympathetic nervous system; [¹¹C]hydroxyephedrine

This article has been cited by other articles:

				A. N. Mazzadi, J. Pineau, N. Costes, D. Le Bars, F. Bonnefoi, P. Croisille, R. Porcher, and P. Chevalier Muscarinic Receptor Upregulation in Patients With Myocardial Infarction: A New Paradigm Circ Cardiovasc Imaging, September 1, 2009; 2(5): 365 - 372. [Abstract] [Full Text] [PDF]

				D. M. Raffel, W. Chen, P. S. Sherman, D. L. Gildersleeve, and Y.-W. Jung Dependence of Cardiac 11C-meta-Hydroxyephedrine Retention on Norepinephrine Transporter Density J. Nucl. Med., September 1, 2006; 47(9): 1490 - 1496. [Abstract] [Full Text] [PDF]