AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 285: H2264-H2276, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00531.2003
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/6/H2264    most recent
00531.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wink, D. A.
Right arrow Articles by Paolocci, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wink, D. A.
Right arrow Articles by Paolocci, N.

CALL FOR PAPERS

Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm

David A. Wink,1 Katrina M. Miranda,2 Tatsuo Katori,3 Daniele Mancardi,1 Douglas D. Thomas,1 Lisa Ridnour,1 Michael G. Espey,1 Martin Feelisch,4 Carol A. Colton,5 Jon M. Fukuto,6 Pasquale Pagliaro,7 David A. Kass,3 and Nazareno Paolocci3

1Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; 2Department of Chemistry, University of Arizona, Tucson, Arizona 85721; 3Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287; 4Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130; 5Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710; 6Department of Molecular and Medical Pharmacology, Center for the Health Sciences, University of California, Los Angeles, California 90095; and 7Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, 10041 Orbassano, Italy

Submitted 6 June 2003 ; accepted in final form 3 July 2003

Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions. An imbalance in the production or availability of these species can result in progression of disease. Nitrogen oxide research in the cardiovascular system has primarily focused on the effects of NO and higher oxidation products. However, nitroxyl (HNO), the one-electron-reduction product of NO, has recently been shown to have unique and potentially beneficial pharmacological properties. HNO and NO often induce discrete biological responses, providing an interesting redox system. This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo.

guanosine 3',5'-cyclic monophosphate; calcitonin gene-related peptide; Angeli's salt


Address for reprint requests and other correspondence: D. A. Wink, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. B3-B69, Bethesda, MD 20892 (E-mail: wink{at}box-w.nih.gov).






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.