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This Article Full Text Full Text (PDF) All Versions of this Article: 286/6/H2386    most recent 00682.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Malyar, N. M. Articles by Ritman, E. L. Search for Related Content PubMed PubMed Citation Articles by Malyar, N. M. Articles by Ritman, E. L.

Relationship between arterial diameter and perfused tissue volume in myocardial microcirculation: a micro-CT-based analysis

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905

Submitted 29 July 2003 ; accepted in final form 8 December 2003

The volume of myocardial tissue that is perfused by an epicardial coronary artery has been shown to be predictably related to the diameter of the epicardial arterial lumen. However, to what extent the intramyocardial microvasculature follows the epicardial rules remains unclear. To explore the relationship between the diameter of coronary arterioles and their subsequent perfused myocardial volumes, we quantified the volume of nonperfused myocardium resulting from an embolized arteriole of a certain diameter. We injected a single dose of microspheres selected from one of nine possible microsphere combinations (10, 30, and 100 µm diameter, each at three possible doses) into the left anterior descending coronary and/or left circumflex arteries of seven anesthetized pigs. At postmortem, the coronary arteries were infused with a radiopaque silicon polymer. Embolized myocardium (1 cm³) was scanned with a microcomputerized tomography scanner and resulted in three-dimensional images that consisted of 20 µm/side cubic voxels and a subvolume of the specimen with 4 µm/side cubic voxels. Image analysis provided the number and volumes of myocardial perfusion defects for each size and dose of microspheres. The smallest individual myocardial perfusion defects, which correspond to the volume of myocardium perfused by a single embolized arteriole, were found to be 0.0004 ± 0.0002, 0.02 ± 0.004, and 0.62 ± 0.099 mm³ for the 10-, 30-, and 100-µm microspheres, respectively. The number of myocardial perfusion defects in the embolized myocardium was inversely related to the dose of the injected microspheres. This reflects a clustering behavior that is consistent with a random distribution process of the individual embolized perfusion defects.

coronary; perfusion; defect; microspheres; microcomputer tomography

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