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Effect of aging on renal blood flow velocity during static exercise

¹Division of Cardiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033; and ²Lebanon Department of Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042

Submitted 9 October 2003 ; accepted in final form 6 March 2004

During exercise, activation of the sympathetic nervous system causes reflex renal vasoconstriction. The effects of aging on this reflex are poorly understood. This study evaluated the effects of age on renal vasoconstrictor responses to handgrip. Seven older (65 ± 9 yr) and nine younger (25 ± 2 yr) subjects were studied. Beat-by-beat analyses of changes in renal blood flow velocity (RBV; duplex ultrasound) were performed during two handgrip paradigms. Arterial blood pressure (BP) and heart rate were also measured, and an index of renal vascular resistance (RVR) was calculated (BP/RBV). In protocol 1, fatiguing handgrip [40% of maximal voluntary contraction (MVC)] caused a greater increase in RVR in the older subjects (old 90% ± 15 increase, young 52% ± 4 increase; P = 0.03). During posthandgrip circulatory arrest (isolates muscle metaboreflex), the increases in RVR were only 1/2 of the increase seen at end grip. In protocol 2, 15-s bouts of handgrip at graded intensities led to increases in RVR in both subject groups. This effect was not seen until 50% MVC workload (P < 0.05). RVR responses occurred early and were greater in older than in younger subjects at 50% MVC (32 ± 6% vs. 16 ± 5%; P = 0.02) and 70% MVC (39 ± 11% vs. 24 ± 8%; P = 0.02). Static exercise-induced renal vasoconstriction is enhanced with aging. Because the characteristics of this response suggest a predominant role for mechanoreceptor engagement, we hypothesize that mechanoreceptor responses are augmented with aging.

kidney; sympathetic nervous system

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