HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/2/H760    most recent 00734.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Fujii, N. Articles by Inoue, H. Search for Related Content PubMed PubMed Citation Articles by Fujii, N. Articles by Inoue, H.

Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure

¹Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194; and ²Daiichi Radioisotope Laboratories, Chiba 289-1517, Japan

Submitted 10 November 2003 ; accepted in final form 27 February 2004

Abnormalities in energy metabolism may play an important role in the development of hypertensive heart failure. However, the transition from compensated hypertrophy to heart failure is not fully understood in terms of energy metabolism. In Dahl salt-sensitive (DS) and salt-resistant (DR) rats, myocardial fatty acid and glucose uptake values were determined using ¹³¹I- or ¹²⁵I-labeled 9-methylpentadecanoic acid (¹³¹I- or ¹²⁵I-9MPA), and [¹⁴C]deoxyglucose ([¹⁴C]DG), fatty acid -oxidation was identified using thin-layer chromatography, and insulin-stimulated glucose-uptake was observed using a euglycemic hyperinsulinemic glucose clamp. Six-week-old rats were fed a diet that contained 8% NaCl, which resulted in development of compensated hypertrophy in DS rats at 12 wk of age and ultimately led to heart failure by 18 wk of age. Uptake of [¹⁴C]DG increased markedly with age in the DS rats, whereas ¹³¹I-9MPA uptake was marginally but significantly increased only in animals aged 12 wk. The ratio of ¹²⁵I-9MPA -oxidation metabolites to total uptake in the DS rats was significantly lower (P < 0.05) at 12 (37%) and 18 (34%) wk compared with at 6 (45%) wk. Insulin increased [¹⁴C]DG uptake more than twofold in the DS rats at 6 wk, although this increase was markedly attenuated at 12 and 18 wk (11 and 8%, respectively). Our data suggest that in a hypertrophied heart before heart failure, fatty acid oxidation is impaired and the capacity to increase glucose uptake during insulin stimulation is markedly reduced. These changes in both glucose and fatty acid metabolism that occur in association with myocardial hypertrophy may have a pathogenic role in the subsequent development of heart failure.

cardiac; failure; deoxyglucose; methylpentadecanoic acid; -oxidation; insulin