HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/5/H1957    most recent 00568.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Schwartz, F. Articles by Gavras, H. Search for Related Content PubMed PubMed Citation Articles by Schwartz, F. Articles by Gavras, H.

Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression

¹Department of Medicine, Hypertension and Atherosclerosis Section and ²Genetics Program, Boston University School of Medicine, Boston, Massachusetts 02118

Submitted 10 June 2004 ; accepted in final form 1 July 2004

Although the central role of ANG II in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is not completely understood. With the use of serial analysis of gene expression to assess global transcriptional changes in the heart of mice after continuous 7-day ANG II administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered several novel ANG II targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The serial analysis of gene expression approach to assess the role of ANG II presented in this report provides new venues for inquiries into ANG II-mediated cardiac function.

genome-wide transcriptional profiling; hypertension; cardiac remodeling; hypertrophy; fibrosis

This article has been cited by other articles:

				V. S. Kasi, H. D. Xiao, L. L. Shang, S. Iravanian, J. Langberg, E. A. Witham, Z. Jiao, C. J. Gallego, K. E. Bernstein, and S. C. Dudley Jr. Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H182 - H192. [Abstract] [Full Text] [PDF]

				W. M Maharsy, L. N Kadi, N. G Issa, K. M Bitar, A. H Der-Boghossian, R. Abrahamian, and A. B Bikhazi Cross-talk related to insulin and angiotensin II binding on myocardial remodelling in diabetic rat hearts Journal of Renin-Angiotensin-Aldosterone System, June 1, 2007; 8(2): 59 - 65. [Abstract] [PDF]