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Am J Physiol Heart Circ Physiol 287: H2201-H2208, 2004. First published July 22, 2004; doi:10.1152/ajpheart.00520.2004
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Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors

Yingzi Chang,1 Daming Zhuang,1 Chunxiang Zhang,2,3 and Aviv Hassid1,3

1Departments of Physiology, 2Medicine, and 3Vascular Biology Center, University of Tennessee Health Science Center, Memphis, Tennessee 38163

Submitted 1 June 2004 ; accepted in final form 15 July 2004

Migration and proliferation of vascular smooth muscle cells are key events in injury-induced neointima formation. Several growth factors and ANG II are thought to be involved in neointima formation. A recent report indicated that vascular injury is associated with increased mRNA levels of protein tyrosine phosphatase (PTP)-1B (PTP-1B). In the present study, we tested the following hypotheses: 1) rat carotid artery injury induces the expression of PTP-1B, Src homology-2 domain phosphatase (SHP-2), and PTP-proline, glutamate, serine, and threonine sequence (PEST) protein; and 2) polypeptide growth factors as well as ANG II increase the levels of tyrosine phosphatases in cultured rat aortic smooth muscle cells. We found that vascular injury induced by balloon catheter increases the protein levels of aforementioned phosphatases and that these effects occur in a PTP specific, as well as temporally and regionally specific, manner. Moreover, treatment of cultured primary rat aortic smooth muscle cells with PDGF or bFGF, but not with IGF1, EGF, or ANG II, increases PTP-1B, SHP-2, and PTP-PEST protein levels. These results suggest that increased PDGF and bFGF levels, occurring after vascular injury, may induce expression of several PTPs.

angiotensin II; protein tyrosine phosphatase


Address for reprint requests and other correspondence: A. Hassid, Dept. of Physiology, 894 Union Ave., Memphis, TN 38163 (E-mail: ahassid{at}tennessee.edu)


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CORRIGENDUM

AJP - Heart 2006 290: H1727. [Full Text]  



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