HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/1/H43    most recent 00630.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Ji, H. Articles by Sandberg, K. Search for Related Content PubMed PubMed Citation Articles by Ji, H. Articles by Sandberg, K.

2004 CARDIOVASCULAR AND KIDNEY INVESTIGATORS MEETING

Sex differences in renal injury and nitric oxide production in renal wrap hypertension

¹Center for the Study of Sex Differences, Departments of ²Medicine and ³Physiology and Biophysics, Georgetown University, Washington, DC; ⁴Dipartimento di Scienze e Tecnologie Biofisiche, Mediche ed Odontostomatologiche, University of Genova, Genova, Italy; and ⁵Department of Pharmacology, Michigan State University, East Lansing, Michigan

Submitted 24 June 2004 ; accepted in final form 18 August 2004

To investigate the faster rate of renal disease progression in men compared with women, we addressed the following questions in the renal wrap (RW) model of hypertension: 1) Do sex differences exist in RW-induced renal injury, which are independent of sex differences in blood pressure? 2) Do sex differences in nitric oxide (NO) production exist in RW hypertension? Male (M) and female (F) rats underwent sham-operated (M-Sham, n = 7; F-Sham, n = 10) or RW (M-RW, n = 13; F-RW, n = 14) surgery for 9 wk. Markers of renal injury, including the glomerulosclerosis index (F-RW, 0.70 ± 0.1 vs. M-RW, 2.2 ± 0.6; P < 0.05), mean glomerular volume (F-RW, 1.05 ± 0.050 x 10⁶ vs. M-RW, 1.78 ± 0.15 x 10⁶ µm³; P < 0.001), and proteinuria (F-RW, 68.7 ± 15 vs. M-RW, 124 ± 7.7 mg/day; P < 0.001) were greater in RW males compared with RW females. Endothelial NO synthase protein expression was elevated in the renal cortex (3.2-fold) and medulla (2.2-fold) 9 wk after RW in males, whereas no differences were observed in females. Neuronal NO synthase protein expression was unchanged in the renal cortex in males and in both the renal cortex and medulla in females, whereas in the male medulla, neuronal NOS was decreased by 57%. These data suggest the degree of renal injury is greater in male compared with female rats in RW hypertension despite similar degrees of hypertension and renal function and may involve sex differences in renal NO metabolism.

renal damage; progressive renal disease; endothelial nitric oxide synthase; neuronal nitric oxide synthase; gender differences

This article has been cited by other articles:

				H. Ji, S. Menini, W. Zheng, C. Pesce, X. Wu, and K. Sandberg Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17{beta}-oestradiol regulation of renal pathology in renal wrap hypertension in rats Exp Physiol, May 1, 2008; 93(5): 648 - 657. [Abstract] [Full Text] [PDF]

				V. Thallas-Bonke, S. R. Thorpe, M. T. Coughlan, K. Fukami, F. Y.T. Yap, K. C. Sourris, S. A. Penfold, L. A. Bach, M. E. Cooper, and J. M. Forbes Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product-Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-{alpha}-Dependent Pathway Diabetes, February 1, 2008; 57(2): 460 - 469. [Abstract] [Full Text] [PDF]

				S. B. Ahmed, N. D.L. Fisher, and N. K. Hollenberg Gender and the Renal Nitric Oxide Synthase System in Healthy Humans Clin. J. Am. Soc. Nephrol., September 1, 2007; 2(5): 926 - 931. [Abstract] [Full Text] [PDF]

				J. L. Rogers, A. R. Mitchell, C. Maric, K. Sandberg, A. Myers, and S. E. Mulroney Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R794 - R799. [Abstract] [Full Text] [PDF]

				I. H. Schulman, P. Aranda, L. Raij, M. Veronesi, F. J. Aranda, and R. Martin Response to Surgical Menopause, Salt Sensitivity, and NO Bioavailability in Women Hypertension, September 1, 2006; 48(3): E13 - E13. [Full Text] [PDF]

				A. Kher, K. K. Meldrum, M. Wang, B. M. Tsai, J. M. Pitcher, and D. R. Meldrum Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury Cardiovasc Res, September 1, 2005; 67(4): 594 - 603. [Abstract] [Full Text] [PDF]

				H. Ji, S. Menini, K. Mok, W. Zheng, C. Pesce, J. Kim, S. Mulroney, and K. Sandberg Gonadal steroid regulation of renal injury in renal wrap hypertension Am J Physiol Renal Physiol, March 1, 2005; 288(3): F513 - F520. [Abstract] [Full Text] [PDF]

				C. S. Wilcox and D. Gutterman Focus on oxidative stress in the cardiovascular and renal systems Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H3 - H6. [Full Text] [PDF]