AJP - Heart AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 288: H469-H476, 2005. First published September 16, 2004; doi:10.1152/ajpheart.00723.2004
0363-6135/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/2/H469    most recent
00723.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Skavdahl, M.
Right arrow Articles by Murphy, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Skavdahl, M.
Right arrow Articles by Murphy, E.

Estrogen receptor-{beta} mediates male-female differences in the development of pressure overload hypertrophy

Maryanne Skavdahl,1,4 Charles Steenbergen,4 James Clark,2 Page Myers,2 Tracy Demianenko,2 Lan Mao,5 Howard A. Rockman,5 Kenneth S. Korach,3 and Elizabeth Murphy1

1Laboratories of Signal Transduction, 2Comparative Medicine, and 3Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park; and Departments of 4Pathology and 5Medicine, Duke University School of Medicine, Durham, North Carolina

Submitted 20 July 2004 ; accepted in final form 13 September 2004

The goal of this study was to determine the role of estrogen receptor subtypes in the development of pressure overload hypertrophy in mice. Epidemiological studies have suggested gender differences in the development of hypertrophy and heart disease, but the mechanism and the role of estrogen receptor subtypes are not established. We performed transverse aortic constriction (TAC) and sham operations in male and female wild-type (WT) mice and mice lacking functional estrogen receptor-{alpha} [{alpha}-estrogen receptor knockout ({alpha}-ERKO)] and mice lacking estrogen receptor-{beta} ({beta}-ERKO). Body, heart, and lung weights were measured 2 wk postsurgery. WT male mice subjected to TAC showed a 64% increase in the heart weight-to-body weight ratio (HW/BW) compared with sham, and WT males have increased lung weight at 2 wk. WT female mice subjected to TAC showed a 31% increase in HW/BW compared with sham, which was significantly less than their male counterparts and with no evidence of heart failure. {alpha}-ERKO females developed HW/BW nearly identical to that seen in WT littermate females in response to TAC, indicating that estrogen receptor-{alpha} is not essential for the attenuation of hypertrophy observed in WT females. In contrast, {beta}-ERKO females responded to TAC with a significantly greater increase in HW/BW than WT littermate females. {beta}-ERKO females have lower expression of lipoprotein lipase at baseline than WT or {alpha}-ERKO females. These data suggest an important role for estrogen receptor-{beta} in attenuating the hypertrophic response to pressure overload in females.

lipoprotein lipase; heart


Address for reprint requests and other correspondence: E. Murphy, National Institute of Environmental Health Sciences, MD-D2-03, Box 12233, Research Triangle Park, NC 27709 (E-mail: murphy1.niehs.nih.gov)




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
L. Zelarayan, A. Renger, C. Noack, M.-P. Zafiriou, C. Gehrke, R. van der Nagel, R. Dietz, L. de Windt, and M. W. Bergmann
NF-{kappa}B activation is required for adaptive cardiac hypertrophy
Cardiovasc Res, December 1, 2009; 84(3): 416 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Umar, Y. P. de Visser, P. Steendijk, C. I. Schutte, E. H. Laghmani, G. T. M. Wagenaar, W. H. Bax, E. Mantikou, D. A. Pijnappels, D. E. Atsma, et al.
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension
Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1606 - H1616.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. J. Barrick, A. Dong, R. Waikel, D. Corn, F. Yang, D. W. Threadgill, and S. S. Smyth
Parent-of-origin effects on cardiac response to pressure overload in mice
Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1003 - H1009.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. E. Huggins, C. L. Curl, R. Patel, P. L. McLennan, M. L. Theiss, T. Pedrazzini, S. Pepe, and L. M. D. Delbridge
Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice
Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H957 - H966.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Domingues-Montanari, I. Subirana, M. Tomas, J. Marrugat, and M. Senti
Association between ESR2 Genetic Variants and Risk of Myocardial Infarction
Clin. Chem., July 1, 2008; 54(7): 1183 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. P. Konhilas and L. A. Leinwand
The Effects of Biological Sex and Diet on the Development of Heart Failure
Circulation, December 4, 2007; 116(23): 2747 - 2759.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. Murphy and C. Steenbergen
Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury
Cardiovasc Res, August 1, 2007; 75(3): 478 - 486.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. F. Deschepper and B. Llamas
Hypertensive Cardiac Remodeling in Males and Females: From the Bench to the Bedside
Hypertension, March 1, 2007; 49(3): 401 - 407.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
F. A. Babiker, D. Lips, R. Meyer, E. Delvaux, P. Zandberg, B. Janssen, G. van Eys, C. Grohe, and P. A. Doevendans
Estrogen Receptor {beta} Protects the Murine Heart Against Left Ventricular Hypertrophy
Arterioscler Thromb Vasc Biol, July 1, 2006; 26(7): 1524 - 1530.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y.-C. Hsieh, M. A. Choudhry, H.-P. Yu, T. Shimizu, S. Yang, T. Suzuki, J. Chen, K. I. Bland, and I. H. Chaudry
Inhibition of cardiac PGC-1{alpha} expression abolishes ER{beta} agonist-mediated cardioprotection following trauma-hemorrhage
FASEB J, June 1, 2006; 20(8): 1109 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
L. A. Barouch, D. Gao, L. Chen, K. L. Miller, W. Xu, A. C. Phan, M. M. Kittleson, K. M. Minhas, D. E. Berkowitz, C. Wei, et al.
Cardiac Myocyte Apoptosis Is Associated With Increased DNA Damage and Decreased Survival in Murine Models of Obesity
Circ. Res., January 6, 2006; 98(1): 119 - 124.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. A. Booth, N. R. Obeid, and B. R. Lucchesi
Activation of estrogen receptor-{alpha} protects the in vivo rabbit heart from ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2039 - H2047.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.