| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Raymond and Beverly Sackler Faculty of Exact Sciences, Abramson Center of Medical Physics, Tel Aviv University, Tel Aviv, Israel; and 2Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Submitted 26 April 2004 ; accepted in final form 15 September 2004
A method for the accurate time-domain characterization of respiratory sinus arrhythmia (RSA) pattern is presented and applied to two groups of healthy subjects to lay the baseline of RSA patterns and to underlay their features: response to standing, stability in successive recordings, and individuality of the shape of RSA pattern. RSA pattern is evaluated by selective averaging of heart rate (HR) changes from multiple respiratory cycles over the respiratory phase and represents the complete modulating function of HR by respiration. The RSA pattern is evaluated with free respiration and even in cases of severe arrhythmia. Estimation error is 6–8% in magnitude, phase resolution is 0.2 rad, and sensitivity margin for respiratory-related HR variability (HRV) components is 1%. RSA magnitude, phase lag, and expiration-to-inspiration time ratio are derived in addition to the entire pattern. In a group of 10 healthy young adults, a phase lag difference of 11.4 ± 8.5% (mean ± SD, P < 0.004) was observed between supine and standing postures, possibly ascribed to breathing mechanics. A second group of 15 healthy young adults at supine rest showed stability of the RSA pattern in successive recordings (several weeks apart) as well as individuality among subjects. This may suggest a nonscalar individual long-term index for cardiorespiratory coupling. The method is complementary to the existing statistical and spectral methods. It allows the complete characterization of the primary RSA components and may provide new insight into the effects of vagal activity and changes in clinical conditions.
autonomic function; heart rate variability; integral pulse frequency modulation; modulating function
This article has been cited by other articles:
|
|
 |
|
  C. Julien, M. J. Parkes, S. Y. C. Tzeng, P. Y. W. Sin, P. N. Ainslie, P. van de Borne, J.-O. Fortrat, M.-A. Custaud, C. Gharib, A. Porta, et al. Comments on Point:Counterpoint: Respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism J Appl Physiol, May 1, 2009; 106(5): 1745 - 1749. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Keissar, L. R Davrath, and S. Akselrod Coherence analysis between respiration and heart rate variability using continuous wavelet transform Phil Trans R Soc A, April 13, 2009; 367(1892): 1393 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. C. Tzeng, P. Y. W. Sin, and D. C. Galletly Human sinus arrhythmia: inconsistencies of a teleological hypothesis Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H65 - H70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kotani, K. Takamasu, Y. Jimbo, and Y. Yamamoto Postural-induced phase shift of respiratory sinus arrhythmia and blood pressure variations: insight from respiratory-phase domain analysis Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1481 - H1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Tzeng, P. D. Larsen, and D. C. Galletly Effects of hypercapnia and hypoxemia on respiratory sinus arrhythmia in conscious humans during spontaneous respiration Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2397 - H2407. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
