| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Institut National de la Santé et de la Recherche Médicale U460, Cardiovascular Remodelling, Hôpital Bichat, Paris, France; and 2The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Submitted 7 June 2004 ; accepted in final form 4 October 2004
Extracellular matrix (ECM) molecules such as elastin and collagen provide mechanical support to the vessel wall and are essential for vascular function. Evidence that genetic factors influence aortic ECM composition and organization was concluded from our previous studies showing that the inbred Brown Norway (BN) rat differs significantly from the outbred Long-Evans (LE) and the inbred LOU rat with respect to both thoracic aortic elastin content and internal elastic lamina (IEL) rupture in the abdominal aorta and iliac arteries. Here, we measured aortic elastin and collagen contents as well as factors that may modulate these parameters [insulin growth factor (IGF)-I, transforming growth factor (TGF)-
1, and matrix metalloproteinase (MMP)-2] in seven inbred rat strains, including BN and LOU. We also investigated whether IEL ruptures occur in strains other than BN. We showed that LOU, LE, BN, and Fischer 344 (F344) rats were significantly different for aortic elastin content and elastin-to-collagen ratio, whereas LE, Lewis, WAG, and Wistar-Furth (WF) were similar for these parameters. BN and F344 had the lowest values. BN was the only strain to present numerous IEL ruptures, whereas F344, LE, and WF presented a few and the other strains presented none. In addition, IGF-I and TGF-1 levels in the plasma and aorta differed significantly between strains, suggesting genetic control of their production. Because inbred rat strains provide interesting models for quantitative trait locus analysis, our results concerning elastin, collagen, IEL ruptures, and cytokines may provide a basis for the search for candidate genes involved in the control of these phenotypes.
elastin; collagen; IEL rupture; IGF-I; TGF-1; aorta; rat strain
This article has been cited by other articles:
|
|
 |
|
  L. Kota, H. Schulz, S. Falak, N. Hubner, and M. Osborne-Pellegrin Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria Physiol Genomics, July 1, 2008; 34(2): 215 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Qiu, C. Depre, K. Ghosh, R. G. Resuello, F. F. Natividad, F. Rossi, A. Peppas, Y.-T. Shen, D. E. Vatner, and S. F. Vatner Mechanism of Gender-Specific Differences in Aortic Stiffness With Aging in Nonhuman Primates Circulation, August 7, 2007; 116(6): 669 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kota, M. Osborne-Pellegrin, H. Schulz, J. Behmoaras, M. Coutard, M. Gong, and N. Hubner Quantitative genetic basis of arterial phenotypes in the Brown Norway rat Physiol Genomics, June 19, 2007; 30(1): 17 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Khorram, M. Momeni, M. Desai, and M. G. Ross Nutrient Restriction In Utero Induces Remodeling of the Vascular Extracellular Matrix in Rat Offspring Reproductive Sciences, January 1, 2007; 14(1): 73 - 80. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Llamas, C. Lau, W. A. Cupples, M.-L. Rainville, E. Souzeau, and C. F. Deschepper Genetic Determinants of Systolic and Pulse Pressure in an Intercross Between Normotensive Inbred Rats Hypertension, November 1, 2006; 48(5): 921 - 926. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
