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Microvascular oxygen delivery and consumption following treatment with verapamil

¹Department of Bioengineering, University of California, San Diego, ²La Jolla Bioengineering Institute, La Jolla, California; and ³Division of General and Surgical Intensive Care Medicine, Department of Anesthesia and Critical Care Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria

Submitted 13 September 2004 ; accepted in final form 22 November 2004

The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle relaxation to oxygen consumption of the microvascular wall during verapamil-induced vasodilatation. Verapamil HCl delivered in a 0.1 mg/kg bolus injection followed by a continuous infusion of 0.01 mg·kg^–1·min^–1 caused significant arteriolar dilatation, increased microvascular flow and functional capillary density, and decreased arteriolar vessel wall transmural PO₂ difference. Verapamil caused tissue PO₂ to increase from 25.5 ± 4.1 mmHg under control condition to 32.0 ± 3.7 mmHg during verapamil treatment. Total oxygen released by the microcirculation to the tissue remained the same as at baseline. Maintenance of the same level of oxygen release to the tissue, increased tissue PO₂, and decreased wall oxygen concentration gradient are compatible if vasodilatation significantly lowers vessel wall oxygen consumption, which in this model appears to constitute an important oxygen-consuming compartment. These findings show that treatment with verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation.

vasoactivity; oxygen gradients; tissue oxygenation; microvessel metabolism

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