HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/5/H2332    most recent 00473.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (17) Citing Articles via Google Scholar Google Scholar Articles by Zheng, H. Articles by Patel, K. P. Search for Related Content PubMed PubMed Citation Articles by Zheng, H. Articles by Patel, K. P.

Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska

Submitted 20 May 2004 ; accepted in final form 29 December 2004

Previously, we have demonstrated that an altered endogenous nitric oxide (NO) mechanism within the paraventricular nucleus (PVN) contributes to increased renal sympathetic nerve activity (RSNA) in heart failure (HF) rats. The goal of this study was to examine the effect of exercise training (ExT) in improving the endogenous NO mechanism within the PVN involved in the regulation of RSNA in rats with HF. ExT significantly restored the decreased number of neuronal NO synthase (nNOS)-positive neurons in the PVN (129 ± 17 vs. 99 ± 6). nNOS mRNA expression and protein levels in the PVN were also significantly increased in HF-ExT rats compared with HF-sedentary rats. To examine the functional role of NO within the PVN, an inhibitor of NOS, N^G-monomethyl-L-arginine, was microinjected into the PVN. Dose-dependent increases in RSNA, arterial blood pressure (BP), and heart rate (HR) were produced in all rats. There was a blunted increase in these parameters in HF rats compared with the sham-operated rats. ExT significantly augmented RSNA responses in rats with HF (33% vs. 20% at the highest dose), thus normalizing the responses. The NO donor sodium nitroprusside, microinjected into the PVN, produced dose-dependent decreases in RSNA, BP, and HR in both sham and HF rats. ExT significantly improved the blunted decrease in RSNA in HF rats (36% vs. 17% at the highest dose). In conclusion, our data indicate that ExT improves the altered NO mechanism within the PVN and restores NO-mediated changes in RSNA in rats with HF.

neuronal nitric oxide synthase; neuromodulator; neurohumoral drive; renal sympathetic nerve activity

This article has been cited by other articles:

				Y.-M. Kang, Y. Ma, C. Elks, J.-P. Zheng, Z.-M. Yang, and J. Francis Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-{kappa}B Cardiovasc Res, September 1, 2008; 79(4): 671 - 678. [Abstract] [Full Text] [PDF]

				Y.-M. Kang, Z.-H. Zhang, B. Xue, R. M. Weiss, and R. B. Felder Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H227 - H236. [Abstract] [Full Text] [PDF]

				A. C. Kleiber, H. Zheng, H. D. Schultz, J. D. Peuler, and K. P. Patel Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1863 - R1872. [Abstract] [Full Text] [PDF]

				Y.-X. Pan, L. Gao, W.-Z. Wang, H. Zheng, D. Liu, K. P. Patel, I. H. Zucker, and W. Wang Exercise Training Prevents Arterial Baroreflex Dysfunction in Rats Treated With Central Angiotensin II Hypertension, March 1, 2007; 49(3): 519 - 527. [Abstract] [Full Text] [PDF]

				P. J. Mueller Exercise training attenuates increases in lumbar sympathetic nerve activity produced by stimulation of the rostral ventrolateral medulla J Appl Physiol, February 1, 2007; 102(2): 803 - 813. [Abstract] [Full Text] [PDF]

				M. K. Reddy, H. D. Schultz, H. Zheng, and K. P. Patel Altered nitric oxide mechanism within the paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failure Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H149 - H157. [Abstract] [Full Text] [PDF]

				H. Zheng, Y.-F. Li, I. H. Zucker, and K. P. Patel Exercise training improves renal excretory responses to acute volume expansion in rats with heart failure Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1148 - F1156. [Abstract] [Full Text] [PDF]

				S. Koba, Z. Gao, J. Xing, L. I. Sinoway, and J. Li Sympathetic responses to exercise in myocardial infarction rats: a role of central command Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2735 - H2742. [Abstract] [Full Text] [PDF]

				J. C. Frisbee, J. B. Samora, J. Peterson, and R. Bryner Exercise training blunts microvascular rarefaction in the metabolic syndrome Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2483 - H2492. [Abstract] [Full Text] [PDF]

				Y.-M. Kang, Z.-H. Zhang, R. F. Johnson, Y. Yu, T. Beltz, A. K. Johnson, R. M. Weiss, and R. B. Felder Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Proinflammatory Cytokines and Hypothalamic Activation in Rats With Ischemia-Induced Heart Failure Circ. Res., September 29, 2006; 99(7): 758 - 766. [Abstract] [Full Text] [PDF]

				K. Jackson, H. M. V. Silva, W. Zhang, L. C. Michelini, and J. E. Stern Exercise Training Differentially Affects Intrinsic Excitability of Autonomic and Neuroendocrine Neurons in the Hypothalamic Paraventricular Nucleus J Neurophysiol, November 1, 2005; 94(5): 3211 - 3220. [Abstract] [Full Text] [PDF]