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This Article Full Text Full Text (PDF) All Versions of this Article: 288/5/H2504    most recent 00368.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Heerman, J. R. Articles by Poelaert, J. I. Search for Related Content PubMed PubMed Citation Articles by Heerman, J. R. Articles by Poelaert, J. I.

Echocardiographic assessment of aortic elastic properties with automated border detection in an ICU: in vivo application of the arctangent Langewouters model

¹Intensive Care Department, Ghent University Hospital, ²Hydraulics Laboratory, Institute of Biomedical Technology, and ³Department of Surgery and Anesthesiology of Domestic Animals, Ghent University, Ghent, Belgium

Submitted 13 May 2004 ; accepted in final form 14 December 2004

We studied whether combined pressure and transesophageal ultrasound monitoring is feasible in the intensive care unit (ICU) setting for global cardiovascular hemodynamic monitoring [systemic vascular resistance (SVR) and total arterial compliance (C_PPM)] and direct estimation of local ascending and descending aortic mechanical properties, i.e., distensibility and compliance coefficients (DC and CC). Pressure-area data were fitted to the arctangent Langewouters model, with aortic cross-sectional area obtained via automated border detection. Data were measured in 19 subjects at baseline, during infusion of sodium nitroprusside (SNP), and after washout. SNP infusion lowered SVR from 1.15 ± 0.40 to 0.80 ± 0.32 mmHg·ml^–1·s (P < 0.05), whereas C_PPM increased from 0.87 ± 0.46 to 1.02 ± 0.42 ml/mmHg (P < 0.05). DC and CC increased from 0.0018 ± 0.0007 to 0.0025 ± 0.0009 l/mmHg (P < 0.05) and from 0.0066 ± 0.0028 to 0.0083 ± 0.0026 cm²/mmHg (P < 0.05), respectively, at the descending, but not ascending, aorta. The Langewouters model fitted the descending aorta data reasonably well. Assessment of local mechanical properties of the human ascending aorta in a clinical setting by automated border detection remains technically challenging.

afterload; large artery function; nitroprusside; coronary artery bypass grafting; intensive care unit

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