| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
Submitted 9 December 2004 ; accepted in final form 23 February 2005
A growing body of evidence indicates that heme degradation products may counteract the deleterious consequences of hypoxia and/or ischemia-reperfusion injury. Because heme oxygenase (HO)-1 induction after adverse circulatory conditions is known to be protective, and because females in the proestrus cycle (with high estrogen) have better hepatic function and less hepatic damage than males after trauma-hemorrhage, we hypothesized that estrogen administration in males after trauma-hemorrhage will upregulate HO activity and protect the organs against dysfunction and injury. To test this hypothesis, male Sprague-Dawley rats underwent 5-cm laparotomy and hemorrhagic shock (35–40 mmHg for 93 ± 2 min), followed by resuscitation with four times the shed blood volume in the form of Ringer lactate. 17
-Estradiol and/or the specific HO enzyme inhibitor chromium mesoporphyrin (CrMP) were administered at the end of resuscitation, and the animals were killed 24 h thereafter. Trauma-hemorrhage reduced cardiac output, myocardial contractility, and serum albumin levels. Portal pressure and serum alanine aminotransferase levels were markedly increased under those conditions. These parameters were significantly improved in the 17-estradiol-treated rats. Estradiol treatment also induced increased HO-1 mRNA expression, HO-1 protein levels, and HO enzymatic activity in cardiac and hepatic tissue compared with vehicle-treated trauma-hemorrhage rats. Administration of the HO inhibitor CrMP prevented the estradiol-induced attenuation of shock-induced organ dysfunction and damage. Thus the salutary effects of estradiol administration on organ function after trauma-hemorrhage are mediated in part via upregulation of HO-1 expression and activity.
hemorrhagic shock; heme oxygenase-1; chromium mesoporphyrin; liver; heart
This article has been cited by other articles:
|
|
 |
|
  Y. Ding, Y.-L. Li, and H. D. Schultz Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits J Appl Physiol, July 1, 2008; 105(1): 14 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-T. Hsu, W.-H. Kan, C.-H. Hsieh, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1 Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1825 - R1831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dassen, R. Kamps, C. Punyadeera, F. Dijcks, A. de Goeij, A. Ederveen, G. Dunselman, and P. Groothuis Haemoglobin expression in human endometrium Hum. Reprod., March 1, 2008; 23(3): 635 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Jeschke, W. B. Norbury, C. C. Finnerty, R. P. Mlcak, G. A. Kulp, L. K. Branski, G. G. Gauglitz, B. Herndon, A. Swick, and D. N. Herndon Age Differences in Inflammatory and Hypermetabolic Postburn Responses Pediatrics, March 1, 2008; 121(3): 497 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-T. Hsu, W.-H. Kan, C.-H. Hsieh, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation J. Leukoc. Biol., October 1, 2007; 82(4): 1019 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-T. Hsu, Y.-C. Hsieh, W. H. Kan, J. G. Chen, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2982 - H2987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-P. Yu, S. Yang, Y.-C. Hsieh, M. A. Choudhry, K. I. Bland, and I. H. Chaudry Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1 Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L400 - L406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sato, F. A. Moore, B. C. Kone, L. Zou, M. A. Smith, M. A. Childs, S. Moore-Olufemi, S. G. Schultz, and R. A. Kozar Differential induction of PPAR-{gamma} by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G616 - G623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Szalay, T. Shimizu, T. Suzuki, H.-P. Yu, M. A. Choudhry, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R812 - R818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Di Lisa A Female Way to Protect the Heart: Say NO to Calcium Circ. Res., February 17, 2006; 98(3): 298 - 300. [Full Text] [PDF]
|
|
|
|
|
|
H.-P. Yu, M. A. Choudhry, T. Shimizu, Y.-C. Hsieh, M. G. Schwacha, S. Yang, and I. H. Chaudry Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1 J. Leukoc. Biol., February 1, 2006; 79(2): 277 - 284. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
