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This Article Full Text Full Text (PDF) All Versions of this Article: 289/4/H1542    most recent 01024.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Li, M. Articles by Stallone, J. N. Search for Related Content PubMed PubMed Citation Articles by Li, M. Articles by Stallone, J. N.

Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function

¹Department of Veterinary Physiology and Pharmacology, and ²Michael E. DeBakey Institute for Comparative Cardiovascular Science, College of Veterinary Medicine, Texas A&M University, College Station, Texas

Submitted 7 October 2004 ; accepted in final form 1 June 2005

To determine the roles of estrogen and constrictor prostanoids in vasopressin (VP)-induced contraction of female rat aorta, vascular reactivity to VP was determined in thoracic aortas of intact, ovariectomized, and ovariectomized + estrogen-replaced female rats in the presence of indomethacin (Indo), NS-398, SQ-29,548, or vehicle control. The effects of estrogen on vascular reactivity to the thromboxane A₂ analog U-46619 were also examined. Maximal contractile response to VP in intact female rats (5,567 ± 276 mg/mg of aortic ring wt) was markedly attenuated by ovariectomy (2,485 ± 394 mg; P < 0.001) and restored by estrogen replacement with 17-estradiol (5,059 ± 194 mg; P > 0.1). Indo and NS-398 significantly attenuated maximal responses to VP in intact female rats to a similar extent [3,176 ± 179 (P < 0.0001) and 3,258 ± 152 mg (P < 0.0001), respectively]. Ovariectomy abolished and estrogen replacement restored the inhibitory effects of Indo, NS-398, and SQ-29,548. Contractile responses of rat aorta to U-46619 were significantly greater (P < 0.0001) in females (5,040 ± 238 mg) than in males (3,679 ± 96 mg). Ovariectomy markedly attenuated (3,923 ± 84 mg; P < 0.01) and estrogen replacement restored (5,024 ± 155 mg; P > 0.1) responses to U-46619 in female aortas. These data reveal that estrogen is an important regulator of the contractile responses of female rat aorta to VP, which appears to potentiate both cyclooxygenase-2 and constrictor prostanoid function in the vascular wall.

arginine vasopressin; constrictor prostanoids; indomethacin; NS-398; SQ-29,548; U-46619; vascular reactivity; vasoconstriction

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