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Regulation of capillary hydraulic conductivity in response to an acute change in shear

¹Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania; ²Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana; and ³Department of Biomedical Engineering, The City College of New York, New York, New York

Submitted 16 December 2004 ; accepted in final form 29 June 2005

The effects of mechanical perturbations (shear stress, pressure) on microvascular permeability primarily have been examined in micropipette-cannulated vessels or in endothelial monolayers in vitro. The objective of this study is to determine whether acute changes in blood flow shear stress might influence measurements of hydraulic conductivity (L_p) in autoperfused microvessels in vivo. Rat mesenteric microvessels were observed via intravital microscopy. Occlusion of a third-order arteriole with a micropipette was used to divert and increase flow through a nonoccluded capillary or fourth-order arteriolar branch. Transvascular fluid filtration rate in the branching vessel was measured with a Landis technique. Flow (shear)-induced increases in L_p disappeared within 20–30 s of the removal of the shear and could be eliminated with nitric oxide synthase inhibition. The shear-induced increase in L_p was greater in capillaries compared with terminal arterioles. An acute change in shear may regulate L_p by a nitric oxide-dependent mechanism that displays heterogeneity within a microvascular network.

shear rate; nitric oxide; transvascular filtration

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