HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 290/5/H1830    most recent 00898.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Mukkamala, R. Articles by O'Leary, D. S. Search for Related Content PubMed PubMed Citation Articles by Mukkamala, R. Articles by O'Leary, D. S.

Estimation of arterial and cardiopulmonary total peripheral resistance baroreflex gain values: validation by chronic arterial baroreceptor denervation

¹Department of Electrical and Computer Engineering, Michigan State University, East Lansing; and Departments of ²Physiology and ³Surgery, Wayne State University School of Medicine, Detroit, Michigan

Submitted 23 August 2005 ; accepted in final form 21 November 2005

Feedback control of total peripheral resistance (TPR) by the arterial and cardiopulmonary baroreflex systems is an important mechanism for short-term blood pressure regulation. Existing methods for measuring this TPR baroreflex mechanism typically aim to quantify only the gain value of one baroreflex system as it operates in open-loop conditions. As a result, the normal, integrated functioning of the arterial and cardiopulmonary baroreflex control of TPR remains to be fully elucidated. To this end, the laboratory of Mukkamala et al. (Mukkamala R, Toska K, and Cohen RJ. Am J Physiol Heart Circ Physiol 284: H947–H959, 2003) previously proposed a potentially noninvasive technique for estimating the closed-loop (dimensionless) gain values of the arterial TPR baroreflex (G_A) and the cardiopulmonary TPR baroreflex (G_C) by mathematical analysis of the subtle, beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. Here, we review the technique with additional details and describe its experimental evaluation with respect to spontaneous hemodynamic variability measured from seven conscious dogs, before and after chronic arterial baroreceptor denervation. The technique was able to correctly predict the group-average changes in G_A and G_C that have previously been shown to occur following chronic arterial baroreceptor denervation. That is, reflex control by the arterial TPR baroreflex was virtually abolished (G_A = –2.1 ± 0.6 to 0.3 ± 0.2; P < 0.05), while reflex control by the cardiopulmonary TPR baroreflex more than doubled (G_C = –0.7 ± 0.4 to –1.8 ± 0.2; P < 0.05). With further successful experimental testing, the technique may ultimately be employed to advance the basic understanding of TPR baroreflex functioning in both humans and animals in health and disease.

autonomic nervous system; blood pressure; cardiovascular modeling; hemodynamics; system identification

This article has been cited by other articles:

				A. Porta, F. Aletti, F. Vallais, and G. Baselli Multimodal signal processing for the analysis of cardiovascular variability Phil Trans R Soc A, January 28, 2009; 367(1887): 391 - 409. [Abstract] [Full Text] [PDF]

				X. Chen, J.-K. Kim, J. A. Sala-Mercado, R. L. Hammond, R. I. Elahi, T. J. Scislo, G. Swamy, D. S. O'Leary, and R. Mukkamala Estimation of the total peripheral resistance baroreflex impulse response from spontaneous hemodynamic variability Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H293 - H301. [Abstract] [Full Text] [PDF]