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This Article Full Text Full Text (PDF) All Versions of this Article: 291/1/H351    most recent 00992.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by De Marchi, S. F. Articles by Seiler, C. Search for Related Content PubMed PubMed Citation Articles by De Marchi, S. F. Articles by Seiler, C.

Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans

Department of Cardiology, University Hospital, Bern, Switzerland

Submitted 19 September 2005 ; accepted in final form 17 January 2006

Infarct size (IS) increases with vascular occlusion time, area at risk for infarction, lack of collateral supply, absence of preconditioning, and myocardial demand for O₂ supply. ECG S-T segment elevation is used as a measure of severity of ischemia and a surrogate for IS. This study in 50 patients with coronary artery disease undergoing a first 120-s balloon occlusion of a stenosis sought to determine whether S-T segment elevation, corrected for the above-mentioned variables, in the left coronary artery (LCA group, n = 36) is different from that in the right coronary artery (RCA group, n = 14) territory. After consideration of all known determinants of IS, particularly mass at risk and collateral supply, the LCA territory is more sensitive than the RCA region to a 2-min period of myocardial ischemia.

coronary disease; collateral circulation