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Am J Physiol Heart Circ Physiol 291: H441-H450, 2006. First published February 3, 2006; doi:10.1152/ajpheart.01229.2005
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Is oxygen supply a limiting factor for survival during rewarming from profound hypothermia?

Timofei V. Kondratiev,1,2 Kristina Flemming,1,2 Eivind S. P. Myhre,3 Mikhail A. Sovershaev,4 and Torkjel Tveita1,2,5

1Department of Anesthesiology, Institute of Clinical Medicine, Departments of 2Medical Physiology and 4Biochemistry, Institute of Medical Biology, University of Tromsø, 5Department of Anesthesiology, University Hospital of North Norway, Tromsø; and 3Section of Cardiology, Department of Medicine, Sørlandet Hospital, Kristiansand, Norway

Submitted 21 November 2005 ; accepted in final form 30 January 2006

It has been postulated that unsuccessful resuscitation of victims of accidental hypothermia is caused by insufficient tissue oxygenation. The aim of this study was to test whether inadequate O2 supply and/or malfunctioning O2 extraction occur during rewarming from deep/profound hypothermia of different duration. Three groups of rats (n = 7 each) were used: group 1 served as normothermic control for 5 h; groups 2 and 3 were core cooled to 15°C, kept at 15°C for 1 and 5 h, respectively, and then rewarmed. In both hypothermic groups, cardiac output (CO) decreased spontaneously by >50% in response to cooling. O2 consumption fell to less than one-third during cooling but recovered completely in both groups during rewarming. During hypothermia, circulating blood volume in both groups was reduced to approximately one-third of baseline, indicating that some vascular beds were critically perfused during hypothermia. CO recovered completely in animals rewarmed after 1 h (group 2) but recovered to only 60% in those rewarmed after 5 h (group 3), whereas blood volume increased to approximately three-fourths of baseline in both groups. Metabolic acidosis was observed only after 5 h of hypothermia (15°C). A significant increase in myocardial tissue heat shock protein 70 after rewarming in group 3, but not in group 2, indicates an association with the duration of hypothermia. Thus mechanisms facilitating O2 extraction function well during deep/profound hypothermia, and, despite low CO, O2 supply was not a limiting factor for survival in the present experiments.

resuscitation; oxygen transport; oxygen consumption; heat shock protein 70; blood volume


Address for reprint requests and other correspondence: T. V. Kondratiev, Dept. of Anesthesiology, Institute of Clinical Medicine, Univ. of Tromsø, 9037 Tromsø, Norway (e-mail: timoteik{at}fagmed.uit.no)






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