HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Video All Versions of this Article: 291/3/H1421    most recent 00031.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Mu, J. Articles by Adamson, S. L. Search for Related Content PubMed PubMed Citation Articles by Mu, J. Articles by Adamson, S. L.

Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation

¹Samuel Lunenfeld Research Institute of Mount Sinai Hospital; and Departments of ²Obstetrics and Gynecology and ³Physiology, University of Toronto, Toronto, Ontario, Canada

Submitted 6 January 2006 ; accepted in final form 22 March 2006

In human pregnancy, abnormal placental hemodynamics likely contribute to the etiology of early-onset preeclampsia and fetal intrauterine growth restriction. The mouse is increasingly being deployed to study normal and abnormal mammalian placental development, yet the placental hemodynamics in normal pregnancy in mice is currently unknown. We used ultrasound biomicroscopy to noninvasively image and record Doppler blood velocity waveforms from the maternal and embryonic placental circulations in mice throughout gestation. In the uterine artery, peak systolic velocity (PSV) increased significantly from 23 ± 2 (SE) to 59 ± 3 cm/s, and end-diastolic velocity (EDV) increased from 7 ± 1 to 28 ± 2 cm/s in nonpregnant versus full-term females so that the uterine arterial resistance index (RI) decreased from 0.70 ± 0.02 to 0.53 ± 0.02. Velocities in the maternal arterial canal in the placenta were low and nearly steady and increased from 0.9 ± 0.03 cm/s at embryonic day 10.5 (E10.5) to 2.4 ± 0.07 cm/s at E18.5. PSV in the umbilical artery increased steadily from 0.8 ± 0.1 cm/s at E8.5 to 15 ± 0.6 cm/s at E18.5, whereas PSV in the vitelline artery increased from 0.6 ± 0.1 cm/s at E8.5 to 4 ± 0.2 cm/s at E13.5 and then remained stable to term. In the umbilical artery, the EDV detection rate was 0% at E14.5 and 94% at E18.5, and the RI decreased from 1 to 0.82 ± 0.01 during this interval. We conclude that ultrasound biomicroscopy can be used to monitor placental hemodynamics during pregnancy in mice. These results provide novel information concerning the development of the vitelline and placental circulations in mice and reveal strong similarities in placental hemodynamics between mice and humans.

yolk sac; embryonic development; pregnancy; ultrasound biomicroscope; Doppler ultrasound; blood velocity; fetus

This article has been cited by other articles:

				L.C. Kusinski, P.N. Baker, C.P. Sibley, and M. Wareing In Vitro Assessment of Mouse Uterine and Fetoplacental Vascular Function Reproductive Sciences, August 1, 2009; 16(8): 740 - 748. [Abstract] [PDF]

				S. Navankasattusas, K. J. Whitehead, A. Suli, L. K. Sorensen, A. H. Lim, J. Zhao, K. W. Park, J. D. Wythe, K. R. Thomas, C.-B. Chien, et al. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds Development, February 15, 2008; 135(4): 659 - 667. [Abstract] [Full Text] [PDF]

				S. Verlohren, M. Niehoff, L. Hering, N. Geusens, F. Herse, A. N. Tintu, A. Plagemann, F. LeNoble, R. Pijnenborg, D. N. Muller, et al. Uterine Vascular Function in a Transgenic Preeclampsia Rat Model Hypertension, February 1, 2008; 51(2): 547 - 553. [Abstract] [Full Text] [PDF]