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This Article Full Text Full Text (PDF) All Versions of this Article: 292/5/H2295    most recent 01116.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Böse, D. Articles by Heusch, G. Search for Related Content PubMed PubMed Citation Articles by Böse, D. Articles by Heusch, G.

Release of TNF- during stent implantation into saphenous vein aortocoronary bypass grafts and its relation to plaque extrusion and restenosis

¹Department of Cardiology, ²Institute of Pathophysiology, and ³Department of Clinical Chemistry, University of Essen School of Medicine, Essen; and ⁴Lukaskrankenhaus, Neuss, Germany

Submitted 12 October 2006 ; accepted in final form 2 January 2007

The reduction in plaque volume during stent implantation is associated with the release of particulate debris and plaque-derived soluble substances. We studied the potential release of the proinflammatory cytokine TNF- into the coronary circulation and whether such release is related to the reduction in plaque volume and, possibly, a predictor for restenosis. In 18 male patients (n = 24 stents) with severe stenosis in a saphenous vein aortocoronary bypass graft (SVG), we used a distal balloon occlusion-aspiration device during stent implantation. The aspirate TNF- levels were determined before and after stent implantation and related to the angiographic and intravascular ultrasound-assessed severity of stenosis and restenosis. We found that TNF- is, indeed, released into the aspirate of stented SVG (9 ± 1 and 28 ± 3 pg/ml before and after stent implantation, respectively, P < 0.0001) and that such release is related to the reduction in plaque volume (r = 0.88, P < 0.0001) and associated with restenosis after 5 mo (r = 0.71, P = 0.001). The periprocedural release of plaque-derived TNF- possibly represents the amount and activity of the atherosclerotic process and might be a predictor for restenosis.

atherosclerosis; inflammation; plaque activity

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