HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/6/H3333    most recent 01019.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Lujan, H. L. Articles by DiCarlo, S. E. Search for Related Content PubMed PubMed Citation Articles by Lujan, H. L. Articles by DiCarlo, S. E.

T₅ spinal cord transection increases susceptibility to reperfusion-induced ventricular tachycardia by enhancing sympathetic activity in conscious rats

Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan

Submitted 4 September 2007 ; accepted in final form 8 October 2007

We recently documented that paraplegia (T₅ spinal cord transection) alters cardiac electrophysiology and increases the susceptibility to ventricular tachyarrhythmias induced by programmed electrical stimulation. However, coronary artery occlusion is the leading cause of death in industrially developed countries and will be the major cause of death in the world by the year 2020. The majority of these deaths result from tachyarrhythmias that culminate in ventricular fibrillation. β-Adrenergic receptor antagonists have been shown to reduce the incidence of sudden cardiac death. Therefore, we tested the hypothesis that chronic T₅ spinal cord transection increases the susceptibility to clinically relevant ischemia-reperfusion-induced sustained ventricular tachycardia due to enhanced sympathetic activity. Intact and chronic (4 wk after transection) T₅ spinal cord-transected (T₅X) male rats were instrumented to record arterial pressure, body temperature, and ECG. In addition, a snare was placed around the left main coronary artery. The susceptibility to sustained ventricular tachycardia produced by 2.5 min of occlusion and reperfusion of the left main coronary artery was determined in conscious rats by pulling on the snare. Reperfusion culminated in sustained ventricular tachycardia in 100% of T₅X rats (susceptible T₅X, 10 of 10) and 0% of intact rats [susceptible intact, 0 of 10 (P < 0.05, T₅X vs. intact)]. β-Adrenergic receptor blockade prevented reperfusion-induced sustained ventricular tachycardia in T₅X rats [susceptible T₅X 0 of 8, 0% (P < 0.05)]. Thus paraplegia increases the susceptibility to reperfusion-induced sustained ventricular tachycardia due to enhanced sympathetic activity.

cardiovascular risks; arrhythmia; spinal cord injury

This article has been cited by other articles:

				H. L. Lujan and S. E. DiCarlo Partial Hindlimb Occlusion Reduced the Susceptibility to Sustained Ventricular Tachycardia in Conscious Rats Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2009; 14(3): 199 - 206. [Abstract] [PDF]

				H. L. Lujan, Y. Chen, and S. E. DiCarlo Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1364 - H1372. [Abstract] [Full Text] [PDF]