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This Article Full Text Full Text (PDF) All Versions of this Article: 294/3/H1174    most recent 01236.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Riordan, M. M. Articles by Kovács, S. J. PubMed PubMed Citation Articles by Riordan, M. M. Articles by Kovács, S. J.

The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function

¹Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, and ²Division of Geriatrics and Nutritional Science, Washington University School of Medicine; ³Department of Biomedical Engineering, School of Engineering and Applied Science, Washington University, Saint Louis, Missouri; ⁴Department of Nutrition and Dietetics, Saint Louis University, Saint Louis, Missouri; and ⁵Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanitá, Rome, Italy

Submitted 24 October 2007 ; accepted in final form 21 December 2007

Little is known about the effects of weight loss on diastolic function. Furthermore, it is not known whether both caloric restriction (CR)- and exercise (Ex)-induced weight loss have salutary effects on diastolic function. Therefore, we assessed the effects of yearlong CR (n = 12) and Ex (n = 13) interventions, which induced 12% weight loss, on diastolic function in healthy, nonobese (body mass index = 23.5–29.9 kg/m²) men and women aged 50 to 60 yr. Recordings of Doppler transmitral flow and Doppler tissue imaging were acquired and analyzed by conventional approaches and a validated parameterized diastolic filling (PDF) formalism. Isovolumic relaxation time decreased after weight loss in both groups (P < 0.05). Septal peak early mitral annular velocity (E') increased (P < 0.01) and peak E-wave velocity/E' decreased (P < 0.05) after weight loss in the CR group. Based on the PDF-derived indexes, CR resulted in a decrease in global ventricular stiffness (k) and increases in longitudinal (septal annulus motion) stored elastic strain (x'_o), peak force (k'x'_o), and peak stored strain energy (1/2k'x_o^prime;2). In the Ex group, k was unchanged, although septal x'_o and 1/2k'x_o'2 increased significantly and k'x'_o (P = 0.13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function.

diet; echocardiography; tissue Doppler imaging; diastole