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This Article Full Text Full Text (PDF) All Versions of this Article: 296/1/H119    most recent 01011.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Falcao, S. Articles by Lavoie, J. L. Search for Related Content PubMed PubMed Citation Articles by Falcao, S. Articles by Lavoie, J. L.

Impact of diet and stress on the development of preeclampsia-like symptoms in p57^kip2 mice

¹Research Centre, Centre Hospitalier de l'Université de Montréal-Technopôle Angus, Montréal, ²Department of Biomedical Sciences, Université de Montréal, Montréal, ³Research Centre, Centre hospitalier de l'Université de Montréal-Hôtel-Dieu, Montréal, and ⁴Department of Medicine, Université de Montréal, Montréal, Québec, Canada

Submitted 17 September 2008 ; accepted in final form 28 October 2008

The cyclin-dependent kinase inhibitor p57^kip2 regulates the cell cycle of trophoblastic cells. It has been established by a Japanese group that the heterozygous p57^kip2 knockout (p57^–/+) mice are a good model of preeclampsia as they develop hypertension, proteinuria, and placental pathology. However, apart from the placental pathology, we could not observe these symptoms in our laboratory. Hence, we investigated the impact of diet and stress on this model. To do so, we compared the effects of the Japanese diet to that of the North American diet used by our animal facility. Furthermore, the impact of stress was determined by placing the mice in a restraining device before and at the end of gestation. Although the Japanese diet did not have any impact on blood pressure or proteinuria, the mice did develop endothelial dysfunction, left ventricular hypertrophy, as well as increased placental pathology. Also, all mice had smaller litters when fed the Japanese diet. However, stress response of these mice was not increased during gestation; in fact, a decrease was observed in the p57^–/+ mice, suggesting that this was probably not a player in the development of the pathology. Taken together, these results suggest that other environmental factors may have been implicated in the development of preeclampsia-like symptoms in this animal model. Moreover, we demonstrated that placental pathology and genetic factors are not sufficient to trigger preeclampsia-like symptoms in this model and that the diet might play an important part in the development of this multifactorial disease.

knockout mouse; diet; stress; blood pressure; preeclampsia

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