The relationship between right ventricle afterloading pressure (P) and outflow (Q) was studied in three isolated canine right ventricle (RV) preparations. Right atrial pressure was held constant while graded elevations in P were induced with stepwise occlusions of the right and left branches of the pulmonary artery. P and Q signals were collected and analyzed using a digital computer system. Data were analyzed by assuming a model structure for the RV and comparing resultant model predictions of Q with actual observations. The model structure was modified in accordance with the discrepancy between prediction and observation to improve the model's predictive capability. The initial model tested was the time-varying linear relationship between ventricular volume and pressure. Utilizing this model, accurate predictions of RV outflow in the face of varying pressure afterloads could not be made. The addition of a series resistance to this elementary model resulted in marked improvement in predictive performance. The addition of greater complexity to the model gave only marginal improvement to the model's predictive capability. It was concluded that a time-varying capacitance and series resistance adequately model internal properties of the RV that relate outflow to afterloading pressure.
- Copyright © 1982 the American Physiological Society