Magnetic resonance imaging (MRI) has emerged as a powerful and reliable tool to non-invasively study the cardiovascular system in clinical practice. Because transgenic mouse models have assumed a critical role in cardiovascular research, technological advances in MRI have been extended to mice over the last decade. These have provided critical insights into cardiac and vascular morphology, function, and physiology/pathophysiology in many murine models of heart disease. Further, MR spectroscopy (MRS) has allowed the non-destructive study of myocardial metabolism in both isolated hearts and in intact mice. This article reviews the current techniques and important pathophysiologic insights from the application of MRI/MRS technology to murine models of cardiovascular disease.
- invited review
- Copyright © 2012, American Journal of Physiology - Heart and Circulatory Physiology