Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease with a high risk for sudden cardiac death in young people. As a subtype, hypertrophic obstructive cardiomyopathy (HOCM) additionally has a left ventricular outflow gradient, showing stronger symptoms and requires a different treatment compared to hypertrophic non-obstructive cardiomyopathy (HNCM). In this study our aim was to investigate the regulation of mitochondrial and cardiac remodeling associated long noncoding RNAs (lncRNAs) in blood of patients affected with hypertrophic obstructive and non-obstructive cardiomyopathies. We included 28 HNCM, 57 HOCM and 26 control inviduals. Already known mitochondrial and cardiac remodeling associated lncRNAs uc004cos.4, uc004coz.1, uc004cov.4, uc011mfi.2, uc022bqw.1, uc022bqs.1 and uc022bqu.1 were amplified in serum of these patients and correlated with clinical parameters. Long noncoding RNAs uc004cov.4 and uc022bqu.1 were significantly increased in patients with hypertrophic obstructive cardiomyopathy but not in patients with hypertrophic non-obstructive cardiomyopathy. Using ROC curve analysis lncRNAs uc004cov.4 and uc022bqu.1 were able to identify HOCM patients. In our study we evidenced that the specific mitochondrial long noncoding RNAs uc004cov.4 and uc022bqu.1 were upregulated in patients with hypertrophic obstructive cardiomyopathy and they were also able to identify hypertrophic obstructive cardiomyopathy and could be developed as useful clinical biomarkers in the future.
- hypertrophic cardiomyopathy
- cardiac remodeling
- Copyright © 2016, American Journal of Physiology - Heart and Circulatory Physiology