Increasing evidence suggests that the conditions of retinal microvessels are indicators to a variety of cerebrovascular, neurodegenerative, psychiatric and developmental diseases. Thus, non-invasive visualization of the human retinal microcirculation offers an exceptional opportunity for the investigation of not only the retinal but also cerebral microvasculature. In this review, we show how the conditions of the retinal microvessels could be used to assess the conditions of brain microvessels because of the microvascular network of the retina and brain share in many aspects standard features in development, morphology, function and pathophysiology. Recent techniques and imaging modalities, such as optical coherence tomography (OCT) - allow more precise visualization of various layers of the retina and its microcirculation, providing a "microscope" to brain microvessels. We also review the potential role of retinal microvessels in the risk identification of cerebrovascular and neurodegenerative diseases. The association between vision problems and cerebrovascular and neurodegenerative diseases, as well as the possible role of retinal microvascular imaging biomarkers in cerebrovascular and neurodegenerative screening - their potentials and limitations - are also discussed.
- retinal imaging biomarkers
- optical imaging
- cerebrovascular and neurodegenerative disorders
- optical coherence tomography
- Copyright © 2016, American Journal of Physiology-Heart and Circulatory Physiology