Objective: Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of the normal vessel wall has not been described. Approach and Results: We examined JCR:LA control (+/+) or cp/cp rats fed normal chow diet for 6m or 18m. JCR:LA-cp rats developed multiple features of advanced cystic medial necrosis including 'cysts', increased collagen formation and proteoglycan deposition around cysts, apoptosis of vascular smooth muscle cells, and spotty medial calcification. These appearances began within 6m and were extensive by 18m. JCR:LA-cp rats had reduced medial cellularity, increased medial thickness, and vessel hypoxia that was most marked in the adventitia. Conclusions: The normal chow-fed JCR:LA-cp rat represents a novel rodent model of cystic medial necrosis, associated with multiple metabolic abnormalities, VSMC apoptosis and vessel hypoxia.
- Metabolic syndrome
- Rodent model
- Copyright © 2016, American Journal of Physiology-Heart and Circulatory Physiology