We use many types of equipment and technologies to make our measurements, but give little thought to how they developed. Evolution was once described as a series of recoils from blind alleys, and this is exemplified by the gradual development of the microsphere method of measuring blood flows. The microsphere method is one of the most frequently used methods for measuring blood flow to organs and portions of organs. The method can measure myocardial blood flow with reasonable accuracy (within 10%) down to samples weighing >50mg but probably will not do so for samples weighing 1-10 mg. Microspheres with diameters from 10-15μm provide the best compromise between accurate flow measurement and retention in tissue. Radioactive labels have been almost entirely replaced by fluorescent labels but colored microspheres and neutron-activated labels are also used.
- radioactive microspheres
- fluorescent microspheres
- colored microspheres
- neutron activation
- Copyright © 2017, American Journal of Physiology-Heart and Circulatory Physiology