B cells have emerged as important immune cells in cardiovascular disease. Initial studies suggested that B cells protect against atherosclerosis development. However, subsequent studies demonstrating aggravation of atherosclerosis by B2 cells shed light on the subset-dependent effects of B cells. Here we review the literature that has led to our current understanding of B cell regulation of atherosclerosis, touching on the importance of subsets, local regulation, human translation and therapeutic potential.
- B cells
- cardiovascular disease
- Copyright © 2017, American Journal of Physiology-Heart and Circulatory Physiology