SPECIAL MEDICAL EDITORIALS:

R. English Chapman and Francis G. Spinale

Extracellular protease activation and unraveling of the myocardial interstitium: critical steps toward clinical applications
Am J Physiol Heart Circ Physiol 286: 1-, 2004; doi:10.1152/ajpheart.00609.2003 [Full Text] [PDF]  

EB2003 SYMPOSIUM:

Anthony Kanai and Jim Peterson

Commentary  Function and regulation of mitochondrially produced nitric oxide in cardiomyocytes
Am J Physiol Heart Circ Physiol 286: H11-H12, 2004; doi:10.1152/ajpheart.00776.2003 [Full Text] [PDF]  

Anthony Kanai, Michael Epperly, Linda Pearce, Lori Birder, Mark Zeidel, Susan Meyers, Joel Greenberger, William de Groat, Gerard Apodaca, and James Peterson

Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells
Am J Physiol Heart Circ Physiol 286: H13-H21, 2004; doi:10.1152/ajpheart.00737.2003 [Abstract] [Full Text] [PDF]  

S. L. Elfering, V. L. Haynes, N. J. Traaseth, A. Ettl, and Cecilia Giulivi

Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase
Am J Physiol Heart Circ Physiol 286: H22-H29, 2004. First published October 2, 2003; doi:10.1152/ajpheart.00766.2003 [Abstract] [Full Text] [PDF]  

Kulwant S. Aulak, Thomas Koeck, John W. Crabb, and Dennis J. Stuehr

Dynamics of protein nitration in cells and mitochondria
Am J Physiol Heart Circ Physiol 286: H30-H38, 2004; doi:10.1152/ajpheart.00743.2003 [Abstract] [Full Text] [PDF]  

Paul S. Brookes and Victor M. Darley-Usmar

Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition
Am J Physiol Heart Circ Physiol 286: H39-H46, 2004. First published August 21, 2003; doi:10.1152/ajpheart.00742.2003 [Abstract] [Full Text] [PDF]  

Wei Li, Thomas Jue, John Edwards, Xipping Wang, and Thomas H. Hintze

Changes in NO bioavailabilty regulate cardiac O₂ consumption: control by intramitochondrial SOD2 and intracellular myoglobin
Am J Physiol Heart Circ Physiol 286: H47-H54, 2004. First published August 14, 2003; doi:10.1152/ajpheart.00730.2003 [Abstract] [Full Text] [PDF]  

Jim Peterson, Anthony J. Kanai, and Linda L. Pearce

A mitochondrial role for catabolism of nitric oxide in cardiomyocytes not involving oxymyoglobin
Am J Physiol Heart Circ Physiol 286: H55-H58, 2004; doi:10.1152/ajpheart.00744.2003 [Abstract] [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Maqsood A. Chotani, Srabani Mitra, Baogen Y. Su, Sheila Flavahan, Ali H. Eid, K. Reed Clark, Christine R. Montague, Hervé Paris, Diane E. Handy, and Nicholas A. Flavahan

Regulation of ₂-adrenoceptors in human vascular smooth muscle cells
Am J Physiol Heart Circ Physiol 286: 59-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00268.2003 [Abstract] [Full Text] [PDF]  

ARTICLES:

Jorge Suarez, Darrell D. Belke, Bernd Gloss, Thomas Dieterle, Patrick M. McDonough, Yun-Kyung Kim, Laurence L. Brunton, and Wolfgang H. Dillmann

In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy
Am J Physiol Heart Circ Physiol 286: 68-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00245.2003 [Abstract] [Full Text] [PDF]  

Umberto Campia, Gail Sullivan, Melissa B. Bryant, Myron A. Waclawiw, Michael J. Quon, and Julio A. Panza

Insulin impairs endothelium-dependent vasodilation independent of insulin sensitivity or lipid profile
Am J Physiol Heart Circ Physiol 286: 76-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00539.2003 [Abstract] [Full Text] [PDF]  

Zuyi Yuan, Keisuke Shioji, Yasuki Kihara, Hiroyuki Takenaka, Yoko Onozawa, and Chiharu Kishimoto

Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property
Am J Physiol Heart Circ Physiol 286: 83-, 2004; doi:10.1152/ajpheart.00536.2003 [Abstract] [Full Text] [PDF]  

Hyun-Dong Je, Cynthia Gallant, Paul C. Leavis, and Kathleen G. Morgan

Caveolin-1 regulates contractility in differentiated vascular smooth muscle
Am J Physiol Heart Circ Physiol 286: 91-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00472.2003 [Abstract] [Full Text] [PDF]  

Mahmoud A. Alomari, Angela Solomito, Rafael Reyes, Syed Muaz Khalil, Robert H. Wood, and Michael A. Welsch

Measurements of vascular function using strain-gauge plethysmography: technical considerations, standardization, and physiological findings
Am J Physiol Heart Circ Physiol 286: 99-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00529.2003 [Abstract] [Full Text] [PDF]  

V. V. Iversen, A. Brønstad, E.-A. B. Gjerde, and R. K. Reed

Continuous measurements of plasma protein extravasation with microdialysis after various inflammatory challenges in rat and mouse skin
Am J Physiol Heart Circ Physiol 286: 108-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00542.2003 [Abstract] [Full Text] [PDF]  

Jeffrey J. Bishop, Patricia R. Nance, Aleksander S. Popel, Marcos Intaglietta, and Paul C. Johnson

Relationship between erythrocyte aggregate size and flow rate in skeletal muscle venules
Am J Physiol Heart Circ Physiol 286: 113-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00587.2003 [Abstract] [Full Text] [PDF]  

Chiaki Kamikado, Toshishige Shibamoto, Minoru Hongo, and Shozo Koyama

Effects of Hct and norepinephrine on segmental vascular resistance distribution in isolated perfused rat livers
Am J Physiol Heart Circ Physiol 286: 121-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.01136.2002 [Abstract] [Full Text] [PDF]  

Peter Smetana, Velislav N. Batchvarov, Katerina Hnatkova, A. John Camm, and Marek Malik

Ventricular gradient and nondipolar repolarization components increase at higher heart rate
Am J Physiol Heart Circ Physiol 286: 131-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00479.2003 [Abstract] [Full Text] [PDF]  

Fan Zhang, Jun Ichi Kaide, LiMing Yang, Houli Jiang, Shuo Quan, Rowena Kemp, Weiying Gong, Michael Balazy, Nader G. Abraham, and Alberto Nasjletti

CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin
Am J Physiol Heart Circ Physiol 286: 137-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00678.2002 [Abstract] [Full Text] [PDF]  

Tomotsugu Tabata, Richard A. Grimm, Junko Asada, Zoran B. Popovic, Hirotsugu Yamada, Neil L. Greenberg, Don W. Wallick, Youhua Zhang, Shaowei Zhuang, Kent A. Mowrey, James D. Thomas, and Todor N. Mazgalev

Determinants of LV diastolic function during atrial fibrillation: beat-to-beat analysis in acute dog experiments
Am J Physiol Heart Circ Physiol 286: 145-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00588.2003 [Abstract] [Full Text] [PDF]  

Feilim Mac Gabhann and Aleksander S. Popel

Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells
Am J Physiol Heart Circ Physiol 286: 153-, 2004. First published April 24, 2003; doi:10.1152/ajpheart.00254.2003 [Abstract] [Full Text] [PDF]  

Christopher Lan, Debarsi Das, Andrew Wloskowicz, and Bozena Vollrath

Endothelin-1 modulates hemoglobin-mediated signaling in cerebrovascular smooth muscle via RhoA/Rho kinase and protein kinase C
Am J Physiol Heart Circ Physiol 286: 165-, 2004. First published September 18, 2003; doi:10.1152/ajpheart.00664.2003 [Abstract] [Full Text] [PDF]  

Karen S. Mark, Amanda R. Burroughs, Rachel C. Brown, Jason D. Huber, and Thomas P. Davis

Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature
Am J Physiol Heart Circ Physiol 286: 174-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00669.2002 [Abstract] [Full Text] [PDF]  

Michel Slama, Jwari Ahn, Jasmina Varagic, Dinko Susic, and Edward D. Frohlich

Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age
Am J Physiol Heart Circ Physiol 286: 181-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00642.2003 [Abstract] [Full Text] [PDF]  

Kenneth B. Walsh and Qi Cheng

Intracellular Ca²⁺ regulates responsiveness of cardiac L-type Ca²⁺ current to protein kinase A: role of calmodulin
Am J Physiol Heart Circ Physiol 286: 186-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00272.2003 [Abstract] [Full Text] [PDF]  

Longkun Zhu, Diane Schwegler-Berry, Vince Castranova, and Pingnian He

Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability
Am J Physiol Heart Circ Physiol 286: 195-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00667.2003 [Abstract] [Full Text] [PDF]  

Jureta W. Horton, D. Jean White, and David L. Maass

Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma
Am J Physiol Heart Circ Physiol 286: 202-, 2004. First published September 18, 2003; doi:10.1152/ajpheart.00706.2003 [Abstract] [Full Text] [PDF]  

Tetsuji Miura, Yoshito Ohnuma, Atsushi Kuno, Masaya Tanno, Yoshihiko Ichikawa, Yuichi Nakamura, Toshiyuki Yano, Takayuki Miki, Jun Sakamoto, and Kazuaki Shimamoto

Protective role of gap junctions in preconditioning against myocardial infarction
Am J Physiol Heart Circ Physiol 286: 214-, 2004. First published September 18, 2003; doi:10.1152/ajpheart.00441.2003 [Abstract] [Full Text] [PDF]  

Oguz K. Baskurt, Ozlem Yalcin, Sadi Ozdem, Jonathan K. Armstrong, and Herbert J. Meiselman

Modulation of endothelial nitric oxide synthase expression by red blood cell aggregation
Am J Physiol Heart Circ Physiol 286: 222-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00532.2003 [Abstract] [Full Text] [PDF]  

Yuan-Lin Dong, Sujatha Vegiraju, Madhu Chauhan, Pandu R. R. Gangula, Gary D. V. Hankins, Linda Goodrum, and Chandra Yallampalli

Involvement of calcitonin gene-related peptide in control of human fetoplacental vascular tone
Am J Physiol Heart Circ Physiol 286: 230-, 2004; doi:10.1152/ajpheart.00140.2003 [Abstract] [Full Text] [PDF]  

Zhihua Jiang, Lizhen Wu, Brett L. Miller, Darin R. Goldman, Chessy M. Fernandez, Zaher S. Abouhamze, C. Keith Ozaki, and Scott A. Berceli

A novel vein graft model: adaptation to differential flow environments
Am J Physiol Heart Circ Physiol 286: 240-, 2004. First published September 18, 2003; doi:10.1152/ajpheart.00760.2003 [Abstract] [Full Text] [PDF]  

Laurent Argaud, Annie-France Prigent, Lara Chalabreysse, Joseph Loufouat, Michel Lagarde, and Michel Ovize

Ceramide in the antiapoptotic effect of ischemic preconditioning
Am J Physiol Heart Circ Physiol 286: 246-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00638.2003 [Abstract] [Full Text] [PDF]  

A. R. Judge and S. L. Dodd

Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle after contractile claudication
Am J Physiol Heart Circ Physiol 286: 252-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00684.2003 [Abstract] [Full Text] [PDF]  

Geneviève Vincent, Bertrand Bouchard, Maya Khairallah, and Christine Des Rosiers

Differential modulation of citrate synthesis and release by fatty acids in perfused working rat hearts
Am J Physiol Heart Circ Physiol 286: 257-, 2004. First published August 21, 2003; doi:10.1152/ajpheart.00717.2003 [Abstract] [Full Text] [PDF]  

Ellen H. Hollander, Gary M. Dobson, Jiun-Jr Wang, Kim H. Parker, and John V. Tyberg

Direct and series transmission of left atrial pressure perturbations to the pulmonary artery: a study using wave-intensity analysis
Am J Physiol Heart Circ Physiol 286: 267-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00505.2002 [Abstract] [Full Text] [PDF]  

Steven P. Jones, James J. M. Greer, Aman K. Kakkar, P. Derek Ware, Richard H. Turnage, Michael Hicks, Rien van Haperen, Rini de Crom, Seinosuke Kawashima, Mitsuhiro Yokoyama, and David J. Lefer

Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury
Am J Physiol Heart Circ Physiol 286: 276-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00129.2003 [Abstract] [Full Text] [PDF]  

Christian Bollensdorff, Andreas Knopp, Christoph Biskup, Thomas Zimmer, and Klaus Benndorf

Na⁺ current through K_ATP channels: consequences for Na⁺ and K⁺ fluxes during early myocardial ischemia
Am J Physiol Heart Circ Physiol 286: 283-, 2004. First published August 14, 2003; doi:10.1152/ajpheart.00232.2003 [Abstract] [Full Text] [PDF]  

Lacy L. Kolo, Thomas C. Westfall, and Heather Macarthur

Nitric oxide decreases the biological activity of norepinephrine resulting in altered vascular tone in the rat mesenteric arterial bed
Am J Physiol Heart Circ Physiol 286: 296-, 2004; doi:10.1152/ajpheart.00668.2003 [Abstract] [Full Text] [PDF]  

Padmaja Koneru and Charles W. Leffler

Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets
Am J Physiol Heart Circ Physiol 286: 304-, 2004; doi:10.1152/ajpheart.00810.2003 [Abstract] [Full Text] [PDF]  

Yuanna Cheng, Li Li, Vladimir Nikolski, Don W. Wallick, and Igor R. Efimov

Shock-induced arrhythmogenesis is enhanced by 2,3-butanedione monoxime compared with cytochalasin D
Am J Physiol Heart Circ Physiol 286: 310-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00092.2003 [Abstract] [Full Text] [PDF]  

Huilin Li, Weinong Guo, Kathryn A. Yamada, and Jeanne M. Nerbonne

Selective elimination of I_K,slow1 in mouse ventricular myocytes expressing a dominant negative Kv1.5 subunit
Am J Physiol Heart Circ Physiol 286: 319-, 2004. First published October 2, 2003; doi:10.1152/ajpheart.00665.2003 [Abstract] [Full Text] [PDF]  

Geun Hee Seol, Seung Cheol Ahn, Ji Aee Kim, Bernd Nilius, and Suk Hyo Suh

Inhibition of endothelium-dependent vasorelaxation by extracellular K⁺: a novel controlling signal for vascular contractility
Am J Physiol Heart Circ Physiol 286: 329-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00503.2003 [Abstract] [Full Text] [PDF]  

Barbara Tribl, Ryon M. Bateman, Stephanie Milkovich, William J. Sibbald, and Christopher G. Ellis

Effect of nitric oxide on capillary hemodynamics and cell injury in the pancreas during Pseudomonas pneumonia-induced sepsis
Am J Physiol Heart Circ Physiol 286: 340-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00234.2003 [Abstract] [Full Text] [PDF]  

Christopher R. Anderson, Ana M. Ponce, and Richard J. Price

Absence of OX-43 antigen expression in invasive capillary sprouts: identification of a capillary sprout-specific endothelial phenotype
Am J Physiol Heart Circ Physiol 286: 346-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00772.2003 [Abstract] [Full Text] [PDF]  

Wenguang Zhang, Dayuan Li, and Jawahar L. Mehta

Role of AIF in human coronary artery endothelial cell apoptosis
Am J Physiol Heart Circ Physiol 286: 354-, 2004; doi:10.1152/ajpheart.00579.2003 [Abstract] [Full Text] [PDF]  

Xiaohui Zhang, Aileen Chen, Dina De Leon, Hong Li, Eisei Noiri, Vincent T. Moy, and Michael S. Goligorsky

Atomic force microscopy measurement of leukocyte-endothelial interaction
Am J Physiol Heart Circ Physiol 286: 359-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00491.2003 [Abstract] [Full Text] [PDF]  

Sodikdjon A. Kodirov, Michael Brunner, Jeanne M. Nerbonne, Peter Buckett, Gary F. Mitchell, and Gideon Koren

Attenuation of I_K,slow1 and I_K,slow2 in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias
Am J Physiol Heart Circ Physiol 286: 368-, 2004; doi:10.1152/ajpheart.00303.2003 [Abstract] [Full Text] [PDF]  

Jason D. Stoner, Mark G. Angelos, and Thomas L. Clanton

Myocardial contractile function during postischemic low-flow reperfusion: critical thresholds of NADH and O₂ delivery
Am J Physiol Heart Circ Physiol 286: 375-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00436.2003 [Abstract] [Full Text] [PDF]  

Ling Chen, Chang Xun Chen, Xiaohong Tracey Gan, Norbert Beier, Wolfgang Scholz, and Morris Karmazyn

Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition
Am J Physiol Heart Circ Physiol 286: 381-, 2004; doi:10.1152/ajpheart.00602.2003 [Abstract] [Full Text] [PDF]  

Shane A. Phillips, E. B. Olson, Barbara J. Morgan, and Julian H. Lombard

Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries
Am J Physiol Heart Circ Physiol 286: 388-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00683.2003 [Abstract] [Full Text] [PDF]  

J. Waschke, W. Baumgartner, R. H. Adamson, M. Zeng, K. Aktories, H. Barth, C. Wilde, F. E. Curry, and D. Drenckhahn

Requirement of Rac activity for maintenance of capillary endothelial barrier properties
Am J Physiol Heart Circ Physiol 286: 394-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00221.2003 [Abstract] [Full Text] [PDF]  

H. E. Cooper, T. H. Clutton-Brock, and M. J. Parkes

Contribution of the respiratory rhythm to sinus arrhythmia in normal unanesthetized subjects during positive-pressure mechanical hyperventilation
Am J Physiol Heart Circ Physiol 286: 402-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00504.2003 [Abstract] [Full Text] [PDF]  

V. P. Nikolski, A. T. Sambelashvili, V. I. Krinsky, and I. R. Efimov

Effects of electroporation on optically recorded transmembrane potential responses to high-intensity electrical shocks
Am J Physiol Heart Circ Physiol 286: 412-, 2004. First published October 2, 2003; doi:10.1152/ajpheart.00689.2003 [Abstract] [Full Text] [PDF]  

Dao-Yi Yu and Stephen J. Cringle

Low oxygen consumption in the inner retina of the visual streak of the rabbit
Am J Physiol Heart Circ Physiol 286: 419-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00643.2003 [Abstract] [Full Text] [PDF]  

Meizi Zheng, Keith Dilly, Jader Dos Santos Cruz, Manxiang Li, Yusu Gu, Jeanine A. Ursitti, Ju Chen, John Ross, Jr., Kenneth R. Chien, Jonathan W. Lederer, and Yibin Wang

Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart
Am J Physiol Heart Circ Physiol 286: 424-, 2004. First published September 11, 2003; doi:10.1152/ajpheart.00110.2003 [Abstract] [Full Text] [PDF]  

Carmit Levy and Amir Landesberg

Hystereses in the force-length relation and regulation of cross-bridge recruitment in tetanized rat trabeculae
Am J Physiol Heart Circ Physiol 286: 434-, 2004. First published September 18, 2003; doi:10.1152/ajpheart.00354.2003 [Abstract] [Full Text] [PDF]  

Andrew C. Betik, Victoria B. Luckham, and Richard L. Hughson

Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions
Am J Physiol Heart Circ Physiol 286: 442-, 2004. First published August 28, 2003; doi:10.1152/ajpheart.00314.2003 [Abstract] [Full Text] [PDF]  

Qi Fu, Armin Arbab-Zadeh, Merja A. Perhonen, Rong Zhang, Julie H. Zuckerman, and Benjamin D. Levine

Hemodynamics of orthostatic intolerance: implications for gender differences
Am J Physiol Heart Circ Physiol 286: 449-, 2004. First published October 2, 2003; doi:10.1152/ajpheart.00735.2002 [Abstract] [Full Text] [PDF]  

Deborah A. Scheuer, Andrea G. Bechtold, Sylvan S. Shank, and Susan F. Akana

Glucocorticoids act in the dorsal hindbrain to increase arterial pressure
Am J Physiol Heart Circ Physiol 286: 458-, 2004. First published September 25, 2003; doi:10.1152/ajpheart.00824.2003 [Abstract] [Full Text] [PDF]  

Olaf Oldenburg, Qining Qin, Thomas Krieg, Xi-Ming Yang, Sebastian Philipp, Stuart D. Critz, Michael V. Cohen, and James M. Downey

Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoK_ATP channel opening and leads to cardioprotection
Am J Physiol Heart Circ Physiol 286: 468-, 2004. First published September 4, 2003; doi:10.1152/ajpheart.00360.2003 [Abstract] [Full Text] [PDF]  

CORRIGENDA:

Corrigenda
Am J Physiol Heart Circ Physiol 286: 477-477, 2004; doi:10.1152/ajpheart.00973.2003 [Full Text] [PDF]  

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