TRANSLATIONAL PHYSIOLOGY:

Heather L. Bartlett, Thomas D. Scholz, Fred S. Lamb, and Daniel L. Weeks

Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging
Am J Physiol Heart Circ Physiol 286: H2035-H2041, 2004; 10.1152/ajpheart.00807.2003 [Abstract] [Full Text] [PDF]  

ARTICLES:

Frédéric Dandré and Gary K. Owens

Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes
Am J Physiol Heart Circ Physiol 286: H2042-H2051, 2004. First published January 29, 2004; 10.1152/ajpheart.00625.2003 [Abstract] [Full Text] [PDF]  

Erik N. T. P. Bakker, Oana Sorop, Jos A. E. Spaan, and Ed VanBavel

Remodeling of resistance arteries in organoid culture is modulated by pressure and pressure pulsation and depends on vasomotion
Am J Physiol Heart Circ Physiol 286: H2052-H2056, 2004. First published February 12, 2004; 10.1152/ajpheart.00978.2003 [Abstract] [Full Text] [PDF]  

Thomas L'Ecuyer, Zuhair Allebban, Ronald Thomas, and Richard Vander Heide

Glutathione S-transferase overexpression protects against anthracycline-induced H9C2 cell death
Am J Physiol Heart Circ Physiol 286: H2057-H2064, 2004. First published January 15, 2004; 10.1152/ajpheart.00778.2003 [Abstract] [Full Text] [PDF]  

Ana M. Gómez, Benoît-Gilles Kerfant, Guy Vassort, and Achilles J. Pappano

Autonomic regulation of calcium and potassium channels is oppositely modulated by microtubules in cardiac myocytes
Am J Physiol Heart Circ Physiol 286: H2065-H2071, 2004. First published January 22, 2004; 10.1152/ajpheart.00933.2003 [Abstract] [Full Text] [PDF]  

Angela M. Park, Chung-Chuan Chou, Paul C. Drury, Yuji Okuyama, Anish Peter, Akira Hamabe, Yasushi Miyauchi, Robert M. Kass, Hrayr S. Karagueuzian, Michael C. Fishbein, Shien-Fong Lin, and Peng-Sheng Chen

Thoracic vein ablation terminates chronic atrial fibrillation in dogs
Am J Physiol Heart Circ Physiol 286: H2072-H2077, 2004. First published January 29, 2004; 10.1152/ajpheart.00595.2003 [Abstract] [Full Text] [PDF]  

Blanca Rodríguez, Brock M. Tice, James C. Eason, Felipe Aguel, José M. Ferrero, Jr., and Natalia Trayanova

Effect of acute global ischemia on the upper limit of vulnerability: a simulation study
Am J Physiol Heart Circ Physiol 286: H2078-H2088, 2004. First published January 29, 2004; 10.1152/ajpheart.01175.2003 [Abstract] [Full Text] [PDF]  

Brian B. Roman, Paul H. Goldspink, Elyse Spaite, Dalia Urboniene, Ron McKinney, David L. Geenen, R. John Solaro, and Peter M. Buttrick

Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo
Am J Physiol Heart Circ Physiol 286: H2089-H2095, 2004. First published January 15, 2004; 10.1152/ajpheart.00582.2003 [Abstract] [Full Text] [PDF]  

Outi Saijonmaa, Tuulikki Nyman, Pia Stewen, and Frej Fyhrquist

Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells
Am J Physiol Heart Circ Physiol 286: H2096-H2102, 2004. First published January 2, 2004; 10.1152/ajpheart.00894.2003 [Abstract] [Full Text] [PDF]  

Daming Zhuang, Alice-Corina Ceacareanu, Yi Lin, Bogdan Ceacareanu, Madhulika Dixit, Kenneth E. Chapman, Christopher M. Waters, Gadiparthi N. Rao, and Aviv Hassid

Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H₂O₂ levels: essential role of cGMP
Am J Physiol Heart Circ Physiol 286: H2103-H2112, 2004. First published January 29, 2004; 10.1152/ajpheart.01118.2003 [Abstract] [Full Text] [PDF]  

Kevin D. Monahan, Iratxe Eskurza, and Douglas R. Seals

Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men
Am J Physiol Heart Circ Physiol 286: H2113-H2117, 2004. First published February 12, 2004; 10.1152/ajpheart.01054.2003 [Abstract] [Full Text] [PDF]  

Zoltán Spolarics, Michael R. Condon, Muhammad Siddiqi, George W. Machiedo, and Edwin A. Deitch

Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice
Am J Physiol Heart Circ Physiol 286: H2118-H2126, 2004. First published January 29, 2004; 10.1152/ajpheart.01085.2003 [Abstract] [Full Text] [PDF]  

Marilyn J. Cipolla, Lisa Vitullo, and John McKinnon

Cerebral artery reactivity changes during pregnancy and the postpartum period: a role in eclampsia?
Am J Physiol Heart Circ Physiol 286: H2127-H2132, 2004. First published January 29, 2004; 10.1152/ajpheart.01154.2003 [Abstract] [Full Text] [PDF]  

Tania Costoli, Alessandro Bartolomucci, Gallia Graiani, Donatella Stilli, Giovanni Laviola, and Andrea Sgoifo

Effects of chronic psychosocial stress on cardiac autonomic responsiveness and myocardial structure in mice
Am J Physiol Heart Circ Physiol 286: H2133-H2140, 2004. First published February 12, 2004; 10.1152/ajpheart.00869.2003 [Abstract] [Full Text] [PDF]  

Yifei Huang, Stephen N. Hunyor, Lele Jiang, Osamu Kawaguchi, Kazuaki Shirota, Yoshihiko Ikeda, Takeshi Yuasa, Gabrielle Gallagher, Biao Zeng, and Xing Zheng

Remodeling of the chronic severely failing ischemic sheep heart after coronary microembolization: functional, energetic, structural, and cellular responses
Am J Physiol Heart Circ Physiol 286: H2141-H2150, 2004; 10.1152/ajpheart.00829.2003 [Abstract] [Full Text] [PDF]  

Wendell S. Akers and Lisa A. Cassis

Presynaptic modulation of evoked NE release contributes to sympathetic activation after pressure overload
Am J Physiol Heart Circ Physiol 286: H2151-H2158, 2004. First published February 5, 2004; 10.1152/ajpheart.00887.2003 [Abstract] [Full Text] [PDF]  

Kuniaki Nakanishi, Hiroshi Osada, Maki Uenoyama, Fumiko Kanazawa, Nobuhiro Ohrui, Yoshinori Masaki, Takuya Hayashi, Yasuhiro Kanatani, Tomosumi Ikeda, and Toshiaki Kawai

Expressions of adrenomedullin mRNA and protein in rats with hypobaric hypoxia-induced pulmonary hypertension
Am J Physiol Heart Circ Physiol 286: H2159-H2168, 2004. First published January 8, 2004; 10.1152/ajpheart.00846.2003 [Abstract] [Full Text] [PDF]  

Hong Han, Hong Long, Huizhen Wang, Jingxiong Wang, Yiqiang Zhang, and Zhiguo Wang

Progressive apoptotic cell death triggered by transient oxidative insult in H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanisms
Am J Physiol Heart Circ Physiol 286: H2169-H2182, 2004. First published January 22, 2004; 10.1152/ajpheart.00199.2003 [Abstract] [Full Text] [PDF]  

Aleksandre T. Sambelashvili, Vladimir P. Nikolski, and Igor R. Efimov

Virtual electrode theory explains pacing threshold increase caused by cardiac tissue damage
Am J Physiol Heart Circ Physiol 286: H2183-H2194, 2004. First published January 15, 2004; 10.1152/ajpheart.00637.2003 [Abstract] [Full Text] [PDF]  

Vijay U. Rao, Hirokazu Shiraishi, and Paul J. McDermott

PKC- regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth
Am J Physiol Heart Circ Physiol 286: H2195-H2203, 2004. First published February 19, 2004; 10.1152/ajpheart.00475.2003 [Abstract] [Full Text] [PDF]  

Qinghang Liu and Polly A. Hofmann

Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes
Am J Physiol Heart Circ Physiol 286: H2204-H2212, 2004. First published February 12, 2004; 10.1152/ajpheart.01050.2003 [Abstract] [Full Text] [PDF]  

Shuchong Pan, Rajiv Gulati, Cheryl S. Mueske, Tyra A. Witt, Amir Lerman, John C. Burnett, Jr., and Robert D. Simari

Gene transfer of a novel vasoactive natriuretic peptide stimulates cGMP and lowers blood pressure in mice
Am J Physiol Heart Circ Physiol 286: H2213-H2218, 2004. First published February 12, 2004; 10.1152/ajpheart.00465.2003 [Abstract] [Full Text] [PDF]  

Atsuko Yatani, Song-Jung Kim, Raymond K. Kudej, Qian Wang, Christophe Depre, Keiichi Irie, Evangelia G. Kranias, Stephen F. Vatner, and Dorothy E. Vatner

Insights into cardioprotection obtained from study of cellular Ca²⁺ handling in myocardium of true hibernating mammals
Am J Physiol Heart Circ Physiol 286: H2219-H2228, 2004. First published February 12, 2004; 10.1152/ajpheart.01096.2003 [Abstract] [Full Text] [PDF]  

Wei Li, David Knowlton, Donna M. Van Winkle, and Beth A. Habecker

Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons
Am J Physiol Heart Circ Physiol 286: H2229-H2236, 2004. First published January 15, 2004; 10.1152/ajpheart.00768.2003 [Abstract] [Full Text] [PDF]  

J. Michael O'Donnell, Raymond K. Kudej, Kathyrn F. LaNoue, Stephen F. Vatner, and E. Douglas Lewandowski

Limited transfer of cytosolic NADH into mitochondria at high cardiac workload
Am J Physiol Heart Circ Physiol 286: H2237-H2242, 2004. First published January 29, 2004; 10.1152/ajpheart.01113.2003 [Abstract] [Full Text] [PDF]  

Beatrijs Bartelds, Janny Takens, Gioia B. Smid, Victor A. Zammit, Carina Prip-Buus, Jaap R. G. Kuipers, and Feike R. van der Leij

Myocardial carnitine palmitoyltransferase I expression and long-chain fatty acid oxidation in fetal and newborn lambs
Am J Physiol Heart Circ Physiol 286: H2243-H2248, 2004. First published January 29, 2004; 10.1152/ajpheart.00864.2003 [Abstract] [Full Text] [PDF]  

Dong Sun, An Huang, Ellen H. Yan, Zhiping Wu, Changdong Yan, Pawel M. Kaminski, Tim D. Oury, Michael S. Wolin, and Gabor Kaley

Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats
Am J Physiol Heart Circ Physiol 286: H2249-H2256, 2004. First published January 29, 2004; 10.1152/ajpheart.00854.2003 [Abstract] [Full Text] [PDF]  

Noriko Niwa, Kenji Yasui, Tobias Opthof, Haruki Takemura, Atsuya Shimizu, Mitsuru Horiba, Jong-Kook Lee, Haruo Honjo, Kaichiro Kamiya, and Itsuo Kodama

Ca_v3.2 subunit underlies the functional T-type Ca²⁺ channel in murine hearts during the embryonic period
Am J Physiol Heart Circ Physiol 286: H2257-H2263, 2004. First published February 26, 2004; 10.1152/ajpheart.01043.2003 [Abstract] [Full Text] [PDF]  

Joseph Francis, Yi Chu, Alan Kim Johnson, Robert M. Weiss, and Robert B. Felder

Acute myocardial infarction induces hypothalamic cytokine synthesis
Am J Physiol Heart Circ Physiol 286: H2264-H2271, 2004; 10.1152/ajpheart.01072.2003 [Abstract] [Full Text] [PDF]  

Toru Kawada, Kazunori Uemura, Koji Kashihara, Atsunori Kamiya, Masaru Sugimachi, and Kenji Sunagawa

A derivative-sigmoidal model reproduces operating point-dependent baroreflex neural arc transfer characteristics
Am J Physiol Heart Circ Physiol 286: H2272-H2279, 2004. First published February 12, 2004; 10.1152/ajpheart.00787.2003 [Abstract] [Full Text] [PDF]  

Yimin Qin, Terry L. Vanden Hoek, Kim Wojcik, Travis Anderson, Chang-Qing Li, Zuo-Hui Shao, Lance B. Becker, and Kimm J. Hamann

Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion
Am J Physiol Heart Circ Physiol 286: H2280-H2286, 2004. First published February 19, 2004; 10.1152/ajpheart.01063.2003 [Abstract] [Full Text] [PDF]  

Ilia Ferrusi, Jun Zhao, Dirk van Helden, and Pierre-Yves von der Weid

Cyclopiazonic acid decreases spontaneous transient depolarizations in guinea pig mesenteric lymphatic vessels in endothelium-dependent and -independent manners
Am J Physiol Heart Circ Physiol 286: H2287-H2295, 2004. First published February 19, 2004; 10.1152/ajpheart.00739.2003 [Abstract] [Full Text] [PDF]  

Yasuhiro Nishikawa, David W. Stepp, Daphne Merkus, Deron Jones, and William M. Chilian

In vivo role of heme oxygenase in ischemic coronary vasodilation
Am J Physiol Heart Circ Physiol 286: H2296-H2304, 2004; 10.1152/ajpheart.00671.2003 [Abstract] [Full Text] [PDF]  

Samia Ben Lamine, Pascale Calabrese, Hélène Perrault, Tuan Pham Dinh, André Eberhard, and Gila Benchetrit

Individual differences in respiratory sinus arrhythmia
Am J Physiol Heart Circ Physiol 286: H2305-H2312, 2004. First published January 29, 2004; 10.1152/ajpheart.00655.2003 [Abstract] [Full Text] [PDF]  

Jennifer C. Hirsch, Andrea R. Borton, Faris P. Albayya, Mark W. Russell, Richard G. Ohye, and Joseph M. Metzger

Comparative analysis of parvalbumin and SERCA2a cardiac myocyte gene transfer in a large animal model of diastolic dysfunction
Am J Physiol Heart Circ Physiol 286: H2314-H2321, 2004; 10.1152/ajpheart.01137.2003 [Abstract] [Full Text] [PDF]  

Tasmia Duza and Ingrid H. Sarelius

Localized transient increases in endothelial cell Ca²⁺ in arterioles in situ: implications for coordination of vascular function
Am J Physiol Heart Circ Physiol 286: H2322-H2331, 2004. First published February 12, 2004; 10.1152/ajpheart.00006.2004 [Abstract] [Full Text] [PDF] [supplemental videos]  

Elizabeth M. Cherry and Flavio H. Fenton

Suppression of alternans and conduction blocks despite steep APD restitution: electrotonic, memory, and conduction velocity restitution effects
Am J Physiol Heart Circ Physiol 286: H2332-H2341, 2004. First published January 29, 2004; 10.1152/ajpheart.00747.2003 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Fei Hua, David C. Johns, and Robert F. Gilmour, Jr.

Suppression of electrical alternans by overexpression of HERG in canine ventricular myocytes
Am J Physiol Heart Circ Physiol 286: H2342-H2351, 2004. First published February 12, 2004; 10.1152/ajpheart.00793.2003 [Abstract] [Full Text] [PDF]  

P. F. Dillon, R. S. Root-Bernstein, and C. M. Lieder

Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle
Am J Physiol Heart Circ Physiol 286: H2353-H2360, 2004. First published February 19, 2004; 10.1152/ajpheart.00968.2003 [Abstract] [Full Text] [PDF]  

Xiaomei Guo and Ghassan S. Kassab

Distribution of stress and strain along the porcine aorta and coronary arterial tree
Am J Physiol Heart Circ Physiol 286: H2361-H2368, 2004; 10.1152/ajpheart.01079.2003 [Abstract] [Full Text] [PDF]  

G. Taimor, K.-D. Schlüter, P. Best, S. Helmig, and H. M. Piper

Transcription activator protein 1 mediates - but not -adrenergic hypertrophic growth responses in adult cardiomyocytes
Am J Physiol Heart Circ Physiol 286: H2369-H2375, 2004. First published February 5, 2004; 10.1152/ajpheart.00741.2003 [Abstract] [Full Text] [PDF]  

Kazunori Uemura, Masaru Sugimachi, Toru Kawada, Atsunori Kamiya, Yintie Jin, Koji Kashihara, and Kenji Sunagawa

A novel framework of circulatory equilibrium
Am J Physiol Heart Circ Physiol 286: H2376-H2385, 2004. First published February 5, 2004; 10.1152/ajpheart.00654.2003 [Abstract] [Full Text] [PDF]  

Nasser M. Malyar, Mario Gössl, Patricia E. Beighley, and Erik L. Ritman

Relationship between arterial diameter and perfused tissue volume in myocardial microcirculation: a micro-CT-based analysis
Am J Physiol Heart Circ Physiol 286: H2386-H2392, 2004. First published December 11, 2003; 10.1152/ajpheart.00682.2003 [Abstract] [Full Text] [PDF]  

Alexander Burashnikov, Sandeep Mannava, and Charles Antzelevitch

Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect of I_Kr and I_Kur/I_to block
Am J Physiol Heart Circ Physiol 286: H2393-H2400, 2004; 10.1152/ajpheart.01242.2003 [Abstract] [Full Text] [PDF]  

Hiroshi Ashikaga, Jeffrey H. Omens, Neil B. Ingels, Jr., and James W. Covell

Transmural mechanics at left ventricular epicardial pacing site
Am J Physiol Heart Circ Physiol 286: H2401-H2407, 2004. First published January 29, 2004; 10.1152/ajpheart.01013.2003 [Abstract] [Full Text] [PDF]  

Steven E. Whitesall, Janet B. Hoff, Alan P. Vollmer, and Louis G. D'Alecy

Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods
Am J Physiol Heart Circ Physiol 286: H2408-H2415, 2004. First published February 12, 2004; 10.1152/ajpheart.01089.2003 [Abstract] [Full Text] [PDF]  

Andrew W. Bowman and Sándor J. Kovács

Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study
Am J Physiol Heart Circ Physiol 286: H2416-H2424, 2004. First published January 29, 2004; 10.1152/ajpheart.00969.2003 [Abstract] [Full Text] [PDF] [Supplemental Video]  

Atsushi Morimoto, Hiroshi Hasegawa, Heng-Jie Cheng, William C. Little, and Che-Ping Cheng

Endogenous ₃-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure
Am J Physiol Heart Circ Physiol 286: H2425-H2433, 2004. First published February 12, 2004; 10.1152/ajpheart.01045.2003 [Abstract] [Full Text] [PDF]  

Blake D. Anson, Michael J. Ackerman, David J. Tester, Melissa L. Will, Brian P. Delisle, Corey L. Anderson, and Craig T. January

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels
Am J Physiol Heart Circ Physiol 286: H2434-H2441, 2004. First published February 19, 2004; 10.1152/ajpheart.00891.2003 [Abstract] [Full Text] [PDF]  

Ikuyo Kusaka, Gen Kusaka, Changman Zhou, Mami Ishikawa, Anil Nanda, D. Neil Granger, John H. Zhang, and Jiping Tang

Role of AT₁ receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury
Am J Physiol Heart Circ Physiol 286: H2442-H2451, 2004; 10.1152/ajpheart.01169.2003 [Abstract] [Full Text] [PDF]  

Thomas H. Everett, IV, Sander Verheule, Emily E. Wilson, Scott Foreman, and Jeffrey E. Olgin

Left atrial dilatation resulting from chronic mitral regurgitation decreases spatiotemporal organization of atrial fibrillation in left atrium
Am J Physiol Heart Circ Physiol 286: H2452-H2460, 2004. First published February 12, 2004; 10.1152/ajpheart.01032.2003 [Abstract] [Full Text] [PDF] [Supplemental Videos]  

INNOVATIVE METHODOLOGY:

Rainer Wessely, Makarios Paschalidis, Stefan Wagenpfeil, Franziska Wegener, Franz-Josef Neumann, and Wolfram Theiss

A comprehensive approach to visual and functional assessment of experimental vascular lesions in vivo
Am J Physiol Heart Circ Physiol 286: H2461-H2467, 2004. First published March 4, 2004; 10.1152/ajpheart.01068.2003 [Abstract] [Full Text] [PDF]  

REPORTS:

Ahmed Tawakol, Torbjørn Omland, and Mark A. Creager

Direct effect of ethanol on human vascular function
Am J Physiol Heart Circ Physiol 286: H2468-H2473, 2004. First published February 5, 2004; 10.1152/ajpheart.01207.2003 [Abstract] [Full Text] [PDF]  

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